Pelletier et al., Cancer Res 2007
:
Nucleophosmin protein accumulation was dependent on mammalian target of rapamycin (mTOR) activation, as rapamycin completely prevented nucleophosmin induction
Marzec et al., Oncogene 2007
(Lymphoma, T-Cell) :
The NPM/ALK induced mTOR activation is transduced through the mitogen induced extracellular kinase ( MEK ) /extracellular signal regulated kinase ( ERK ) signaling pathway and, to a much lesser degree, through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B ( Akt ) pathway