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FKBP1A — MTOR

Pathways - manually collected, often from reviews:

• WikiPathways Target Of Rapamycin (TOR) Signaling: FKBP1A → Complex of RPTOR-MLST8-MTOR (inhibition)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: FKBP1A — MTOR Jacinto et al., Nat Cell Biol 2004
• IRef Bind Interaction: FKBP1A — MTOR Choi et al., Science 1996*
• IRef Bind_translation Interaction: FKBP1A — MTOR (coimmunoprecipitation) Jacinto et al., Nat Cell Biol 2004
• IRef Bind_translation Interaction: FKBP1A — MTOR (x-ray crystallography) Choi et al., Science 1996*
• IRef Biogrid Interaction: FKBP1A — MTOR (physical association, affinity chromatography technology) Sarbassov et al., Curr Biol 2004
• IRef Biogrid Interaction: FKBP1A — MTOR (physical association, affinity chromatography technology) Jacinto et al., Nat Cell Biol 2004
• IRef Biogrid Interaction: FKBP1A — MTOR (association, x-ray crystallography) Choi et al., Science 1996*
• IRef Biogrid Interaction: FKBP1A — MTOR (direct interaction, two hybrid) Luker et al., Proc Natl Acad Sci U S A 2004*
• IRef Biogrid Interaction: FKBP1A — MTOR (direct interaction, pull down) Sabers et al., J Biol Chem 1995*
• IRef Biogrid Interaction: FKBP1A — MTOR (direct interaction, pull down) Banaszynski et al., J Am Chem Soc 2005*
• IRef Hprd Interaction: FKBP1A — MTOR (in vitro) Liang et al., Acta Crystallogr D Biol Crystallogr 1999*, Choi et al., Science 1996*
• IRef Innatedb Interaction: FKBP1A — MTOR (unknown, -) Hara et al., J Biol Chem 1997*
• IRef Intact Interaction: FKBP1A — MTOR (direct interaction, x-ray crystallography) Liang et al., Acta Crystallogr D Biol Crystallogr 1999*
• IRef Ophid Interaction: FKBP1A — MTOR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Aoki et al., Proc Natl Acad Sci U S A 2001 (Cell Transformation, Neoplastic) : Rapamycin inhibits the kinase mTOR , an important regulator of translation, and this inhibition requires binding of the antibiotic to the immunophilin FKBP12
Lawrence et al., Curr Top Microbiol Immunol 2004 : In contrast, rapamycin-FKBP12 inhibited mTOR activity towards both PHAS-I and p70S6K, although this complex inhibited the phosphorylation of some sites more than that of others
Oshiro et al., Genes Cells 2004 : Rapamycin, in the presence of FKBP12 , inhibited the association of raptor with mTOR directly in vitro, and concomitantly reduced the mTOR catalysed phosphorylation of raptor dependent, but not raptor independent substrates ; mTOR autophosphorylation was unaltered
Sarbassov et al., Curr Biol 2004 : Consistent with this finding, the rictor containing mTOR complex contains GbetaL but not raptor and it neither regulates the mTOR effector S6K1 nor is it bound by FKBP12-rapamycin
Hoeffer et al., Neuron 2008 (Synaptic Transmission) : Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior
Martín-Cano et al., Aging 2013 : Mobilization of intracellular Ca2+ stores through IP3R or RyR channels was impaired in aged cells, and it was facilitated by mTOR and by FKBP12, as indicated by the inhibitory effects of KU0063794 ( a direct mTOR inhibitor ), rapamycin ( a FKBP12 mediated mTOR inhibitor ) and FK506 ( an FKBP12 binding immunosuppressant )