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GRAP2 — NOS2

Text-mined interactions from Literome

Feng et al., J Immunol 1999 : Extracellular signal related kinase ( ERK ) and p38 mitogen activated protein ( MAP ) kinases differentially regulate the lipopolysaccharide mediated induction of inducible nitric oxide synthase and IL-12 in macrophages : Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase
Song et al., J Trauma 2002 (Sepsis) : iNOS gene deficiency inhibited p38 MAPK activation in splenic T cells taken from septic mice, and also suppressed IL-10 release in both sham and septic mice
Gutiérrez-Venegas et al., Life Sci 2005 : We conclude that p38 is critically involved in i-NOS induction, and that it participates in COX-2 expression and in PGE2 synthesis
Kao et al., Immunology 2005 : Based on those findings, we suggest that LTA might activate the PI3K/Akt pathway through tyrosine kinase to induce p38 MAPK activation, which in turn initiates NF-kappaB activation, and ultimately induces iNOS expression and NO release in RAW 264.7 macrophages
Sung et al., J Neurochem 2005 (Hyperalgesia) : Inhibition of p38 mitogen activated protein kinase attenuates interleukin-1beta induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord
Lee et al., Infect Immun 2005 : TNF-alpha and NOS2 levels correlated with and were dependent on the activation of mitogen activated protein kinases ( MAPKs ) p38 and extracellular signal regulated kinase 1/2 ( ERK1/2 )
Xu et al., Life Sci 2006 (Nerve Degeneration...) : Inhibition of p38 effectively reduced iNOS mRNA expression and rescued neurons from apoptosis and death in the area adjacent to the lesion epicenter ; whereas the inhibition of ERK1/2 had a smaller effect on decrease of iNOS mRNA and no long-term protective effect on cell loss
Kim et al., J Pharmacol Exp Ther 2007 : In addition, a c-Jun NH ( 2 ) -terminal kinase ( JNK ) inhibitor anthra [ 1,9-cd ] pyrazole-6 ( 2H ) -one ) ( SP600125 ) but not an extracellular regulated kinase inhibitor [ 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD98029 ) ] or a p38 inhibitor [ 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imidazole ( SB230580 ) ] reduced the iNOS protein level induced by LPS
Gong et al., Am J Nephrol 2010 : Initiation of IH-induced apoptosis was mediated by upregulation of Bax and downregulation of Bcl-2 and Mcl-1, which was preceded by p38 MAPK activation and iNOS induction
Yasuda et al., Clin Rheumatol 2010 (Arthritis, Rheumatoid) : When the RA cartilage explants or the isolated RA chondrocytes in monolayer were incubated with FN-f, the fragment stimulated NO production with induction of inducible nitric oxide synthase (iNOS) and activation of p38 mitogen activated protein kinase
Puthanveetil et al., Free Radic Biol Med 2011 : PA-treated cardiomyocytes showed a substantial increase in TG accumulation, accompanied by amplification of nuclear migration of phospho-p38 and FoxO1, iNOS induction , and translocation of CD36 to the plasma membrane
Gong et al., Ren Fail 2012 (Acute Kidney Injury...) : Furthermore, pretreatment with SB203580 and NACA not only attenuated the pro-apoptotic effect of Gen, but also significantly reversed its effects on p38 MAPK phosphorylation and iNOS induction
Liu et al., Biomaterials 2013 (Brain Ischemia) : Furthermore, CBSA-PEG-TIIA-NPs significantly decreased the mRNA expressions of iNOS and p38MAPK , upregulated PPAR? expression, and inhibited the protein levels of iNOS , GFAP and p38MAPK phosphorylation
Huang et al., Toxicol Appl Pharmacol 2013 (Inflammation) : We also found that LTA induced iNOS and COX-2 up-regulation were attenuated by p38 , JNK, and PI3-kinase inhibitors