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CAPN1 — CASP12

Text-mined interactions from Literome

Ruiz-Vela et al., EMBO J 1999 : We demonstrate that calpain specifically triggers activation and processing of caspase-7 both in vitro and in vivo, and that both processes are inhibited by calpain inhibitors
Chua et al., J Biol Chem 2000 (Calcium Signaling) : Furthermore, direct cleavage of caspase-9 by calpain blocks dATP and cytochrome-c induced caspase-3 activation
Büki et al., J Neurosci 2000 (Brain Injuries...) : Furthermore, D-IFHC revealed a colocalization of calpain activation, cyto-c release, and caspase-3 induction in these foci, which also revealed progressive TAI
Nakagawa et al., J Cell Biol 2000 : Activation of caspase-12 by calpain in apoptosis ... We propose that disturbance to intracellular calcium storage as a result of ischemic injury or amyloid beta peptide cytotoxicity may induce apoptosis through calpain- mediated caspase-12 activation and Bcl-xL inactivation
White et al., J Neurol Sci 2000 (Brain Ischemia...) : Although rigorous study of multi-drug protocols is very demanding, effective therapy is likely to require ( 1 ) peptide growth factors for early activation of survival signaling pathways and recovery of translation competence, ( 2 ) inhibition of lipid peroxidation, ( 3 ) inhibition of calpain , and ( 4 ) caspase inhibition
Choi et al., J Neurochem 2001 (Necrosis) : Cleavage of Bax is mediated by caspase dependent or -independent calpain activation in dopaminergic neuronal cells : protective role of Bcl-2
Varghese et al., Eur J Immunol 2001 : The role of calpain in caspase activation during etoposide induced apoptosis in T cells
Yeo et al., Cancer Lett 2002 (Ovarian Neoplasms) : These results suggested that Bax cleavage is mediated by calpain, and calpain activation may be a caspase dependent one ... Taken together, the chemopreventive effects of Se-MSC may be related in part to the caspase-3 activation, the down-regulation of IAP family proteins, and Bax cleavage mediated by caspase dependent calpain activation
Gylys et al., Neurochem Res 2002 : Staurosporine induced loss of neuronal particles was blocked by nonselective caspase inhibition ( z-VAD-fmk ) and by calpain inhibition ( calpain inhibitor II [ ALLM ] )
McCollum et al., J Neurochem 2002 : Calpain inhibitor III ( MDL-28170 ) reduced caspase activation, suggesting that caspase activation was mediated by calpain
Emgård et al., Neuroscience 2002 (Nerve Degeneration) : Interestingly, extensive degradation of caspase-3 occurred already directly after dissection and was at least partly calpain dependent
Hwang et al., Int J Oncol 2003 : These results suggested that Bax cleavage is mediated by calpain, and calpain activation may be caspase dependent ... Taken together, the apoptotic effects of NPPA may be related, in part to the caspase-3 activation, the down-regulation of XIAP, and Bax cleavage mediated by caspase dependent calpain activation
Daniel et al., Int J Mol Med 2003 (Autolysis...) : Furthermore, pretreatment with the specific pharmacological calpain inhibitor calpeptin blocked the drug induced calpain small subunit autolysis and calpain activation in mitochondria and inhibited apoptosis associated caspase-3 activation, demonstrating that mitochondrial calpain activation through small subunit cleavage is an essential step for inducing tumor cell apoptosis by various anticancer drugs
Bizat et al., J Biol Chem 2003 (Neurodegenerative Diseases) : Results showed that 3NP induced death of striatal neurons was preceded by cytochrome c redistribution, transient caspase-9 processing, and activation of calpain , whereas levels of the active/processed form of caspase-3 remained low and were even reduced as compared with control animals
Kim et al., J Biol Chem 2003 : Interestingly, the overexpression of parkin induced the activation of an intracellular cysteine protease, calpain, but not caspase , and the cytoprotective effect of parkin on alpha-synuclein cytotoxicity was significantly inhibited by the presence of calpain-specific inhibitors
Altznauer et al., J Biol Chem 2004 (Cystic Fibrosis) : Calpain-1 regulates Bax and subsequent Smac dependent caspase-3 activation in neutrophil apoptosis
Sribnick et al., J Neurosci Res 2004 : Glutamate induced apoptosis correlated with upregulation of calpain , a proapoptotic shift in the Bax : Bcl-2 ratio, and increased activation of caspase-3
Bonomini et al., Journal of thrombosis and haemostasis : JTH 2004 (Chronic Disease...) : PS exposure in agonist stimulated platelets was markedly reduced by inhibition of caspase-3 activity but was not affected by inhibition of calpain activity
Sergeev et al., Biochem Biophys Res Commun 2004 (Breast Neoplasms) : Selective inhibition of Ca2+ binding sites of mu-calpain , forced increase of the cytosolic Ca2+ buffering capacity, and caspase inhibition decreased apoptotic indices in the genistein treated cells
Plate et al., Leukemia & lymphoma 2004 (Leukemia, Lymphocytic, Chronic, B-Cell) : GSK-3beta a kinase regulated via PI3-kinase dependent, down-stream kinases, was responsible for regulating cyclin D1 levels in CLL cells, but neither GSK-3beta nor calpain was responsible for induction of apoptosis, or activation of executioner caspase 3, following LY294002 treatment
Bernath et al., Neurobiol Aging 2006 : These results point to selective susceptibility of cytoskeletal proteins to calpain mediated degradation, but not caspase-3 in aging rat brains
Nakatsu et al., Neurotoxicology 2006 : In conclusion, we have demonstrated that tributyltin induced cell death through calpain activation, and that intracellular Ca ( 2+ ) increase and caspase-3 activation are required for calpain activation by tributyltin
Karmakar et al., Neuroscience 2006 (Ganglioglioma) : Upregulation of calpain , a Ca2+ dependent cysteine protease, activated caspase-12 that in turn caused activation of caspase-9
Beart et al., J Neurochem 2007 : AMPA mediated apoptosis involved induction of Bax, loss of mitochondrial transmembrane potential ( deltapsi ( m ) ), early release of cytochrome c ( cyt c ), and more delayed release of second mitochondrial activator of caspases ( SMAC ), Omi, and apoptosis inducing factor ( AIF ) with early calpain and minor late activation of caspase 3
Lee et al., Cell Microbiol 2008 : Collectively, these data suggest that Shiga toxins trigger monocytic cell apoptosis through the ER stress response, the increased expression of DR5 and TRAIL, and activation of caspase-8 via a calpain dependent mechanism
Del Río et al., Neurochem Res 2008 : Results show no caspase-3 activity, but a strong calpain activation involving both NMDA and non-NMDA receptors
Chaitanya et al., Neurochem Res 2008 (Brain Ischemia) : Activation of calpain , cathepsin-b and caspase-3 during transient focal cerebral ischemia in rat model
Floyd et al., Prostate Cancer Prostatic Dis 2009 (Prostatic Neoplasms) : To delineate a specific pathway of action for bicalutamide, PC-3 and PWR-1E cells were pretreated with specific inhibitors of caspase dependent ( zVAD-FMK ) and caspase independent pathways ( calpain 2 inhibitor )
Lien et al., Histol Histopathol 2008 (Prostatic Neoplasms) : Blocking the enzyme activity of NQO1 with dicoumarol, a known NQO1 inhibitor, or preventing an increase in intracellular calcium levels using BAPTA-AM, an intracellular calcium chelator, substantially inhibited MAPK phosphorylation, abolished the activation of calpain , caspase-12 and caspase-7, and provided significant protection of beta-lapachone treated cells ... Blocking the enzyme activity of NQO1 with dicoumarol, a known NQO1 inhibitor, or preventing an increase in intracellular calcium levels using BAPTA-AM, an intracellular calcium chelator, substantially inhibited MAPK phosphorylation, abolished the activation of calpain , caspase-12 and caspase-7, and provided significant protection of beta-lapachone treated cells
Li et al., Cardiovasc Res 2009 (Disease Models, Animal...) : gp91(phox)-NADPH oxidase mediated calpain-1 activation induces caspase-3 activation and TNF-alpha expression in cardiomyocytes during LPS stimulation
Sergeev et al., Biochem Biophys Res Commun 2009 (Calcium Signaling...) : Here, we report that 1,25 ( OH ) ( 2 ) D ( 3 ) induces apoptosis in mature mouse 3T3-L1 adipocytes via activation of Ca ( 2+ ) -dependent calpain and Ca ( 2+ ) /calpain dependent caspase-12
Gafni et al., J Biol Chem 2009 : Calpain-1 cleaves and activates caspase-7 ... Our studies suggest the calpain activated form of caspase-7 has unique enzymatic activity, localization, and binding affinity when compared with the caspase activated form
Vaisid et al., Int J Biochem Cell Biol 2009 (Alzheimer Disease...) : The results suggest that procaspase-8 and FLIP ( S ) association with cell membrane receptor complexes is required for calpain induced caspase-8 activation
Liu et al., Int J Cancer 2009 (Adenocarcinoma...) : Inhibition of mu-calpain not only significantly reduced caspase-9/-3 activities but also completely blocked AIF redistribution
Matsuzaki et al., Neurochem Int 2010 : In addition, inhibitors of calpain , which are activated by the Ca ( 2+ ), also inhibited the cleavage of caspase-4
El-Khoury et al., Mol Cancer Ther 2010 (Leukemia, Lymphocytic, Chronic, B-Cell) : Moreover, MGCD0103 treatment resulted in the activation of a caspase cascade downstream of caspase-9, caspase dependent amplification of mitochondrial depolarization, activation of calpain , and Bax cleavage
Hossain et al., Toxicological sciences : an official journal of the Society of Toxicology 2011 : Additional studies demonstrated that deltamethrin exposure activated caspase-12 activity and that pharmacological inhibition and siRNA knockdown of calpain prevented deltamethrin induced DNA fragmentation, thus indicating a role for the endoplasmic reticulum ( ER ) stress pathway
Jantas et al., Neurotoxicology 2011 : The obtained data provided evidence for neuroprotective potency of MAPK/ERK1/2 and calpain , but not caspase-3 inhibition against the neurotoxic effects of LC in primary cortical neurons and give rationale for using these inhibitors in the treatment of neurodegenerative diseases connected with proteasome dysfunction
Hu et al., Inflamm Res 2012 : Amiloride also inhibited calpain and calcineurin expression levels in acid induced chondrocytes, and inhibited caspase-3 activity
Yoo et al., J Biol Chem 2012 (Neoplasms) : In addition, PDT activated calpain was responsible for the sequential events of Bax translocation, the collapse of d? ( m ), caspase-3 activation, and AIF translocation, all of which were provoked by TG2 activation
Nelson et al., Crit Care Med 2012 (Muscular Atrophy) : To test this prediction, we determined whether selective pharmacological inhibition of calpain would prevent activation of caspase-3 and conversely whether selective inhibition of caspase-3 would abate calpain activation ... Pharmacological inhibition of calpain prevented mechanical ventilation induced activation of diaphragmatic caspase-3 and inhibition of caspase-3 prevented activation of diaphragmatic calpain ... Furthermore, calpain inhibition also prevented the activation of caspase-9 and caspase-12, along with the cleavage of Bid to tBid, all upstream signals for caspase-3 activation ... Furthermore, calpain inhibition also prevented the activation of caspase-9 and caspase-12 , along with the cleavage of Bid to tBid, all upstream signals for caspase-3 activation ... Importantly, these findings provide the first experimental evidence in diaphragm muscle that calpain inhibition prevents the activation of caspase-3 and vice versa and caspase-3 inhibition prevents the activation of calpain ... These findings support our hypothesis that a regulatory calpain/caspase-3 cross-talk exists whereby calpain can promote caspase-3 activation and active caspase-3 can enhance calpain activity in diaphragm muscle during prolonged mechanical ventilation
Smith et al., Cardiovasc Res 2012 : In cardiomyocytes, calpain 1 activates caspase 3 and poly-ADP ribose polymerase during tumour necrosis factor-a induced apoptosis, and calpain 1 cleaves apoptosis inducing factor after Ca ( 2+ ) overload
Yang et al., In Vitro Cell Dev Biol Anim 2012 : Here, we conclude that CAPN1 , calpastatin, caspase 3, caspase 7, caspase 8, and CARD9 have important roles for satellite cell myogenesis ; and that caspase 7, 12, HSP70, and HSP90 are involved in the process of apoptotic cell death under hypoxia conditions and we speculate that these proteins may be involved in early postmortem proteolysis and meat tenderization
Melo et al., Neuroscience 2013 : These results translate a time dependent activation of proteases and spatial segregation of these mechanisms, where calpain activation is followed by proteasome deregulation, from neuronal processes to the soma, and finally by caspase activation in the cell body
Li et al., BMC cardiovascular disorders 2013 (Disease Models, Animal...) : The role of the Hsp90/Akt pathway in myocardial calpain induced caspase-3 activation and apoptosis during sepsis ... Recent studies have demonstrated that myocardial calpain triggers caspase-3 activation and myocardial apoptosis in models of sepsis, whereas the inhibition of calpain activity down-regulates myocardial caspase-3 activation and apoptosis ... Myocardial calpain induces myocardial caspase-3 activation and apoptosis in septic mice via the activation of the Hsp90/Akt pathway
Talbert et al., J Appl Physiol 2013 : Interestingly, inhibition of calpain activity also prevented caspase-3 activation, and, conversely, inhibition of caspase-3 prevented calpain activation
Cui et al., PloS one 2013 (Diabetes Mellitus, Type 2) : Moreover, calpain-2 was required for FFA induced expression of CHOP and activation of caspase-12 and caspase-3 , thus promoting cell apoptosis in ß-TC3 cells ... Moreover, calpain-2 was required for FFA induced expression of CHOP and activation of caspase-12 and caspase-3, thus promoting cell apoptosis in ß-TC3 cells
Ozkan et al., Antimicrob Agents Chemother 2013 : Our study shows, for the first time in the literature, that caspase mediated apoptosis, iNOS, caspase 1, and calpain 1 are involved in the pathogenesis of colistin associated nephropathy