Gene interactions and pathways from curated databases and text-mining

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MTOR — ULK1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Jung et al., Mol Biol Cell 2009 : ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery ... Inhibition of mTOR by rapamycin or leucine deprivation, the conditions that induce autophagy, leads to dephosphorylation of ULK1, ULK2, and Atg13 and activates ULK to phosphorylate FIP200 ... These findings demonstrate that the ULK-Atg13-FIP200 complexes are direct targets of mTOR and important regulators of autophagy in response to mTOR signaling
Lee et al., PloS one 2010 : Taken together, these results suggest that AMPK association with ULK1 plays an important role in autophagy induction, at least in part, by phosphorylation of raptor to lift the inhibitory effect of mTOR on the ULK1 autophagic complex
Dunlop et al., Autophagy 2011 : ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding ... Interestingly, ULK1 overexpression also increases phosphorylation of Raptor Ser863 and the mTOR autophosphorylation site, Ser2481 in a mTORC1 dependent manner ... Interestingly, ULK1 overexpression also increases phosphorylation of Raptor Ser863 and the mTOR autophosphorylation site, Ser2481 in a mTORC1 dependent manner ... We propose a new mechanism whereby ULK1 contributes to mTORC1 inhibition through hindrance of substrate docking to Raptor
Shang et al., Autophagy 2011 : These studies show that both mTOR and AMPK directly regulate Ulk1 and coordinate the mammalian autophagy initiation
Jung et al., Autophagy 2011 : ULK1 inhibits the kinase activity of mTORC1 and cell proliferation ... ( 1-3 ) Here, we investigated how ULK1 regulates mTORC1 signaling, and found that ULK1 inhibits the kinase activity of mTORC1 and cell proliferation ... Deficiency or knockdown of ULK1 or its homolog ULK2 enhanced mTORC1 signaling, cell proliferation rates and accumulation of cell mass, whereas overexpression of ULK1 had the opposite effect ... In addition, ULK1 was found to bind raptor, induce its phosphorylation, and inhibit the kinase activity of mTORC1 ... In addition, ULK1 was found to bind raptor, induce its phosphorylation, and inhibit the kinase activity of mTORC1 ... These results demonstrate that ULK1 negatively regulates the kinase activity of mTORC1 and cell proliferation in a manner independent of Atg5 and TSC2
Castets et al., Cell Metab 2013 : In young TSCmKO mice, constitutive and starvation induced autophagy is blocked at the induction steps via mTORC1 mediated inhibition of Ulk1 , despite FoxO3 activation