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MTOR — NF1
Text-mined interactions from Literome
Dasgupta et al., Cancer Res 2005
(Astrocytoma...) :
Recent studies from our laboratory have shown that
neurofibromin also
regulates the
mammalian target of rapamycin activity in a Ras dependent fashion, and that the rapamycin mediated mammalian target of rapamycin inhibition ameliorates the Nf1-/- astrocyte growth advantage
Hegedus et al., Cancer Res 2008
(Disease Models, Animal...) :
Because
neurofibromin negatively
regulates mammalian target of rapamycin
(mTOR) signaling , we showed that pharmacologic mTOR inhibition in vivo led to decreased tumor cell proliferation in a dose dependent fashion associated with a decrease in tumor volume ... Because
neurofibromin negatively
regulates mammalian target of rapamycin (mTOR) signaling, we showed that pharmacologic mTOR inhibition in vivo led to decreased tumor cell proliferation in a dose dependent fashion associated with a decrease in tumor volume
Banerjee et al., Cancer Res 2010
:
The
NF1 gene product neurofibromin negatively
regulates Ras and mammalian target of rapamycin
(mTOR) signaling , prompting clinical trials to evaluate the ability of Ras and mTOR pathway inhibitors to arrest NF1 associated tumor growth