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MAPK15 — UTS2

Text-mined interactions from Literome

Chen et al., Zhonghua Yi Xue Za Zhi 2000 : The effect of Urotensin II-stimulated airway smooth muscle cells DNA synthesis is mediated by Ca2+, PKC, MAPK and CaN signal transduction pathway
Watanabe et al., Circulation 2001 : The synergistic interaction between UII and moxLDL was partially inhibited by anti-Gq/11alpha antibody, the epidermal growth factor receptor tyrosine kinase inhibitor erbstatin A ( 10 micromol/L ), and the intracellular free radical scavenger N-acetylcysteine ( 400 micromol/L ) and was completely inhibited by the c-Src tyrosine kinase inhibitor radicicol ( 10 micromol/L ), the protein kinase C ( PKC ) inhibitor Ro31-8220 ( 0.1 micromol/L ), and the mitogen activated protein kinase ( MAPK ) kinase inhibitor PD098059 ( 10 micromol/L )
Chen et al., Chin Med J (Engl) 2004 : In primary cultures of rat ASMCs, activities of protein kinase C ( PKC ), mitogen activated protein kinase ( MAPK ) and calcineurin ( CaN ) induced by UII were measured ... UII 10 ( -7 ) mol/L stimulated ASMC PKC and MAPK activities by 44 % and 24 % ( P < 0.01 ), respectively, after incubating for 20 minutes ... UII increases cytosolic free calcium concentration and activates PKC, MAPK and CaN