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CCL2 — MAPK15

Text-mined interactions from Literome

Ashida et al., J Biol Chem 2001 : Further, C3 exoenzyme and the Rho kinase inhibitor blocked MCP-1 dependent p38-MAPK activation
Chen et al., Diabetologia 2001 (Diabetes Mellitus, Type 1...) : Both ERK1/2 and p38 MAPK , but not nitric oxide, contribute to MCP-1 expression
Sodhi et al., J Interferon Cytokine Res 2002 : Monocyte chemoattractant protein-1 induced activation of p42/44 MAPK and c-Jun in murine peritoneal macrophages : a potential pathway for macrophage activation ... Furthermore, the MCP-1 induced phosphorylation of p42/44 MAPK was found to be blocked by pertussis toxin ( 100 ng/ml ), tyrosine kinase inhibitor-genestein ( 10 ng/ml ), PI3K inhibitor-wortmannin ( 20-200 microM ), and anti-CCR2 antibody ( 2.5 microg/ml )
Arendt et al., Leukemia 2002 (Multiple Myeloma) : Although MM cell chemotaxis in response to MCP-1 was only minimal, we were able to demonstrate that MCP-1 stimulated activation of MAPK
Rong et al., Arterioscler Thromb Vasc Biol 2002 : Further studies suggested that LPC induced MCP-1 expression partially involves mitogen activated protein kinase/extracellular signal regulated kinase, a tyrosine kinase ( s ), and ( to a lesser extent ) protein kinase C but not the activation of the platelet derived growth factor receptor
Werle et al., Cardiovasc Res 2002 : MCP-1 induces activation of MAP-kinases ERK, JNK and p38 MAPK in human endothelial cells
Takaya et al., American journal of physiology. Renal physiology 2003 (Cell Transformation, Viral) : In this study, we examined whether albumin overload induced MCP-1 expression was regulated by mitogen activated protein kinase ( MAPK ) in mouse proximal tubular ( mProx ) cells
Wuyts et al., Respir Med 2003 (Asthma...) : We conclude that p38 MAPK , JNK kinase, ERK and NF-kappaB are involved in the IL-1beta induced eotaxin, MCP-1 , and MCP-3 expression and release in HASMC
Hirata Terra et al., Anal Biochem 2004 : Here, we describe an alternative bioassay based on MCP-1 induced phosphorylation of the mitogen activated protein kinases ( MAPK ) p44 ( ERK1 ) and p42 ( ERK2 ) ... MCP-1 induced phosphorylation of p44/42 MAPK is dependent upon the expression of CCR2B
Bian et al., Invest Ophthalmol Vis Sci 2004 : The Ly294002-sensitive PI3K/Akt pathway regulates MCP-1 , but not IL-8 expression in hRPE cells independent of MAPK and IkappaB
Chen et al., Am J Physiol Heart Circ Physiol 2004 (Arteriosclerosis) : Treatment of endothelial cells with SphK1 siRNA suppressed TNF-alpha induced increase in MCP-1 mRNA levels, MCP-1 protein secretion, and activation of p38 MAPK
Zeng et al., Acta Pharmacol Sin 2005 : Inhibitors of PKC ( calphostin C, 50-500 nmol/L and RO-31-8220, 10-100 nmol/L ), CaM ( W7, 28-280 micromol/L ), ERK1/2 MAPK ( PD 98059, 2-20 micromol/L ), p38 MAPK ( SB 203580, 0.6-6 micromol/L ), JNK MAPK ( curcumin, 2-10 micromol/L ), and NF-kappaB ( PDTC, 10-100 nmol/L ) markedly reduced Hcy 100 micromol/L induced production of MCP-1 and IL-8 in human cultured whole blood, but the inhibitors of PTK ( genistein, 2.6-26 micromol/L and tyrphostin, 0.5-5 micromol/L ) had no obvious effect on MCP-1 and IL-8 production
Wong et al., Am J Respir Cell Mol Biol 2005 : IL-25 could also activate the JNK, p38 MAPK, and NF-kappaB activities of eosinophils, while inhibitor of IkappaB-alpha phosphorylation ( BAY11-7082 ), JNK ( SP600125 ), and p38 MAPK ( SB203580 ) could suppress the release of IL-8, MIP-1alpha, MCP-1 , and IL-6 ... Together, the above results showed that the induction of MCP-1 , MIP-1alpha, IL-8, and IL-6 in IL-25 activated eosinophils are regulated by JNK, p38 MAPK , and NF-kappaB pathways
Hall et al., J Immunol 2005 : The role of p38 MAPK in rhinovirus induced monocyte chemoattractant protein-1 production by monocytic-lineage cells
Fain et al., Int J Obes Relat Metab Disord 2005 (Obesity) : However, inhibition of MCP-1 release in the presence of inhibitors of both the p38 MAPK and NF-kappaB pathways was greater than that seen with only the NF-kappaB inhibitor
Matsuyama et al., Am J Respir Cell Mol Biol 2005 (Sarcoidosis, Pulmonary) : Activation of DDR1 induced monocyte chemoattractant protein-1 ( MCP-1 ) and matrix metalloproteinase-9 (MMP-9) production in a p38 mitogen activated protein kinase dependent manner from CD14 positive BALF cells of patients with deteriorated sarcoidosis
Hung et al., Pediatr Allergy Immunol 2006 : Montelukast also abolished MCP-1 induced [ Ca2+ ] i and pp38 MAPK expression in THP-1 cells in a dose dependent manner ... This effect may involve the down-regulation of MCP-1 induced [ Ca2+ ] i and p38 MAPK expression
Ip et al., Clin Exp Immunol 2006 (MAP Kinase Signaling System) : Inhibition of p38 MAPK , ERK and JAK-2 activities by pretreating the cells with their corresponding inhibitors SB203580, PD98059 and AG490, respectively, significantly suppressed IL-4- and IL-13 induced MCP-1 production in BEAS-2B cells
Guest et al., Antioxid Redox Signal 2006 (Mechanotransduction, Cellular) : In conclusion, redox-sensitive activation of ERK1/2 ( MAPK ) and redox-insensitive activation of p38 ( MAPK ) regulate straininduced MCP-1 expression in RASM cells
Chung et al., Ann N Y Acad Sci 2007 (Gastritis...) : In an attempt to determine the role of phosphorylation-dephosphorylation in HP99 induced inflammation, we analyzed the expression of protein phosphatases, the activation of MAPK and transcription factors, and the production of chemokine MCP-1 in AGS cells stimulated with HP99 ( at a bacteria-cell ratio of 300 : 1 ) and cultured in the presence or absence of a nonspecific serine-threonine protein phosphatase inhibitor, okadaic acid ( OA )
Watanabe et al., J Immunol 2007 (Pneumonia...) : In this process, an increase of inflammatory cell recruitment, an up-regulation of lung MCP-1 and TGF-beta, and a remarkable activation of p44/42 MAPK in neutrophils were observed
Ip et al., Immunology 2007 (Asthma...) : Selective inhibitors of p38 MAPK ( SB203580 ), ERK ( PD98059 ), and JNK ( SP600125 ) could differentially inhibit the production of EGF, VEGF and CCL2 , thereby suggesting a role for MAPKs in IL-31 functions
Ho et al., Immunobiology 2008 (Inflammation...) : Selective inhibitors of p38 MAPK ( SB203580 ), JNK ( SP600125 ) and ERK ( PD98059 ) could suppress TNF-alpha induced CCL2 and ICAM-1 expression, while only p38 MAPK and ERK inhibitors could suppress TNF-alpha induced VCAM-1 expression
Kim et al., Mol Cells 2008 : In addition, rosmarinic acid reduced cell migration by inducing the expression of a specific chemokine receptor on LPS induced mature BMDCs. Rosmarinic acid also significantly reduced the expressions of MCP-1 and MIP-lalpha induced by LPS in BMDCs and inhibited LPS induced activation of MAPK and the nuclear translocation of NF-kappaB
Liu et al., Horm Metab Res 2009 : In summary, these results suggest that visfatin induced MCP-1 and IL-6 production involve p38 MAPK , PI3K, and ERK 1/2 pathways in human umbilical vein endothelial cells as determined by inhibition with specific inhibitors
Yubero et al., Biochim Biophys Acta 2009 (Pancreatitis) : Pancreatic glutathione depletion, acinar overexpression of monocyte chemoattractant protein-1 ( MCP-1 ) and cytokine induced neutrophil chemoattractant ( CINC ), and activation of p38MAPK , NF-kappaB and STAT3 were found in both AP models
Vrotsos et al., Brain Res Bull 2009 (MAP Kinase Signaling System) : Furthermore, inhibition of either p38 MAPK or JAK signaling pathways significantly reduced APP 's effect on MCP-1 and MCPIP
Sommer et al., Obesity (Silver Spring) 2010 : Signaling studies suggested that p44/42 mitogen activated protein (MAP) kinase is involved in visfatin induced MCP-1 mRNA expression in hMSC-Ads
Iyoda et al., American journal of physiology. Renal physiology 2010 : Additionally, we observed that IL-17A and IL-17F induced MAPK ( p38 MAPK, ERK1/2, and JNK ) activation and that pharmacological inhibitors of p38 MAPK ( SB203580 ) and ERK1/2 ( U0126 ), but not JNK ( SP600125 ), blocked the IL-17A/IL-17F mediated MCP-1 and MIP-2 release
Oyama et al., Lab Invest 2010 (Granuloma...) : HMGB1 also induced MCP-1 secretion through mitogen activated protein kinase ( MAPK ) and phosphoinositide-3-kinase (PI3K) pathways in rat renal tubular epithelial cells in vitro
Monzon et al., Am J Physiol Lung Cell Mol Physiol 2011 (MAP Kinase Signaling System...) : MCP-1 through its receptor CCR2 induces chemotaxis and activates ( 44/42 ) MAPK , a kinase known to play a key role in mucin regulation in bronchial epithelium
Lee et al., J Cardiovasc Pharmacol 2011 (Arrhythmias, Cardiac...) : The suppression of nuclear factor-?B and p38 mitogen activated protein kinase activation and the inhibition of monocyte chemoattractant protein-1 expression contribute to the beneficial effects of wogonin
Choi et al., Fitoterapia 2011 (Leukemia, Monocytic, Acute) : Herein, we investigated the effects of Rh1 on the expression of MCP-1 and CCR2, activation of MAPK signaling, and chemotaxis of monocytes
Huang et al., J Cell Biochem 2012 (Inflammation) : Importantly, NF? B and p38 MAPK signaling pathways, which were activated by NOX derived ROS, were involved in CRP induced monocyte-endothelial cell adhesion and up-regulation of MCP-1 expression
Chen et al., Molecular vision 2011 : Inhibition of p38MAPK , phosphoinositide 3-kinase (PI3K)-Akt and nuclear factor-kappaB ( NF-?B ), with the inhibitors SB203580, LY294002 and pyrrolydine dithiocarbamate ( PDTC ) respectively, reduced IL-17 ( 100 ng/ml ) mediated production of CXCL8, CCL2 , and IL-6 in a concentration dependent manner
Lee et al., J Obstet Gynaecol Res 2012 (Endometriosis...) : The release of MCP-1 by ePF- and cPF treated monocytes was efficiently abrogated by p38 mitogen activated protein kinase ( MAPK ) inhibitors ; however, the MCP-1 release by cPF treated monocytes, but not by ePF treated monocytes, was blocked by a MAPK kinase inhibitor
Voss et al., Inflamm Allergy Drug Targets 2012 : While poly ( I:C ) induced IL-8 gene expression was solely inhibited by the NF-?B inhibitor III, MCP-1 gene induction was also blocked by PKA, p38 MAPK and JAK-STAT inhibitors
Fang et al., J Biol Chem 2012 (Breast Neoplasms...) : RNA interference of CCR2 expression in breast cancer cells significantly inhibited CCL2 induced migration, survival, and phosphorylation of Smad3 and p42/44MAPK proteins ... These data indicate that Smad3 signaling through MEK-p42/44MAPK regulates CCL2 induced cell motility and survival, whereas CCL2 induction of MEK-p42/44MAPK signaling independent of Smad3 functions as an alternative mechanism for cell survival
Burke et al., PloS one 2012 : The IL-1ß mediated increase in CCL2 secretion was also impaired by p38 MAPK inhibition and by glucocorticoids
Wehbe et al., PloS one 2012 (MAP Kinase Signaling System...) : Inhibition of the mitogen activated protein kinase ( MAPK ) activation pathway in Amela tumor lines leads to reduced expression of EMT hallmark genes and inhibits both proinflammatory cytokine Ccl2 gene expression and Ccl2 production by the melanoma cells
Lin et al., PloS one 2012 (Osteoarthritis) : Stimulation of cells with CCL2 increased PKCd and p38MAPK activation