UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to MTOR

MTOR — YWHAQ

Pathways - manually collected, often from reviews:

NCI Pathway Database LKB1 signaling events: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → mTORC1 complex complex (MTOR-MLST8-RPTOR-AKT1S1) (modification, collaborate)
Shaw et al., Cancer Cell 2004, Gwinn et al., Mol Cell 2008
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database LKB1 signaling events: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → mTORC1 complex/14-3-3 family complex (MTOR-MLST8-RPTOR-AKT1S1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
Shaw et al., Cancer Cell 2004, Gwinn et al., Mol Cell 2008
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database LKB1 signaling events: mTORC1 complex complex (MTOR-MLST8-RPTOR-AKT1S1) → mTORC1 complex/14-3-3 family complex (MTOR-MLST8-RPTOR-AKT1S1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
Shaw et al., Cancer Cell 2004, Gwinn et al., Mol Cell 2008
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database mTOR signaling pathway: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) (modification, collaborate)
Gwinn et al., Mol Cell 2008
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database mTOR signaling pathway: 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) → mTORC1/PRAS40/DEPTOR/14-3-3 family complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
Gwinn et al., Mol Cell 2008
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database mTOR signaling pathway: mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR) → mTORC1/PRAS40/DEPTOR/14-3-3 family complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB) (modification, collaborate)
Gwinn et al., Mol Cell 2008
Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Bind Interaction: YWHAQ — MTOR Mori et al., FEBS Lett 2000 *
IRef Bind_translation Interaction: YWHAQ — MTOR (unspecified method) Mori et al., FEBS Lett 2000 *
IRef Biogrid Interaction: YWHAQ — MTOR (physical association, affinity chromatography technology) Meek et al., J Biol Chem 2004
IRef Hprd Interaction: YWHAQ — MTOR (in vitro) Mori et al., FEBS Lett 2000 *
IRef Hprd Interaction: YWHAQ — MTOR (in vivo) Mori et al., FEBS Lett 2000 *
IRef Innatedb Interaction: YWHAQ — MTOR (unknown, -) Mori et al., FEBS Lett 2000 *
IRef Mppi Interaction: YWHAQ — MTOR (coimmunoprecipitation) Mori et al., FEBS Lett 2000 *
IRef Mppi Interaction: YWHAQ — MTOR (far western blotting) Mori et al., FEBS Lett 2000 *
IRef Ophid Interaction: YWHAQ — MTOR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
IRef Ophid Interaction: YWHAQ — MTOR (aggregation, confirmational text mining) Mori et al., FEBS Lett 2000 *