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CASP16 — NOD2

Text-mined interactions from Literome

Rogler et al., Curr Opin Gastroenterol 2004 : Important new insights have been gained into the function of caspase activating and recruitment domain-15 ( CARD15 ) /NOD2 , the first cloned susceptibility gene for Crohn disease ( CD ) ... Important new insights have been gained into the function of caspase activating and recruitment domain-15 ( CARD15 ) /NOD2 , the first cloned susceptibility gene for Crohn disease ( CD )
Ferwerda et al., Eur J Immunol 2008 (Crohn Disease) : Although it is known that NOD2 mediates cytokine responses to muramyl dipeptide ( MDP ), it is yet unclear whether NOD2 stimulation mediates only transcription of pro-IL-1beta mRNA, or whether NOD2 is also involved in the activation of caspase-1 and release of active IL-1beta ... The synergy in IL-1beta production between NOD2 and TLR is mediated at post-translational level in a caspase-1 dependent manner, which indirectly suggests that NOD2 also induces caspase-1 activation
Marina-García et al., J Immunol 2008 : Furthermore, the work provides evidence for distinct roles of Nod2 and Cryopyrin in the regulation of MDP induced caspase-1 activation and IL-1beta secretion
Warren et al., J Immunol 2008 (Listeriosis) : Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection ... We demonstrate that the presence of L. monocytogenes within the cytosolic compartment induces caspase 1 activation through multiple Nod-like receptors, including Ipaf and Nalp3
Hsu et al., Proc Natl Acad Sci U S A 2008 (Anthrax...) : We found that NOD2 through its N-terminal caspase recruitment domain directly binds and activates caspase-1 to trigger IL-1beta processing and secretion in MDP stimulated macrophages, whereas the C-terminal leucine-rich repeats of NOD2 prevent caspase-1 activation in nonstimulated cells
Miao et al., J Clin Immunol 2010 : This proteolysis is dependent upon caspase 1, which is activated by Nod-like receptor ( NLR ) signaling
Meinzer et al., Cell Host Microbe 2012 (Yersinia pseudotuberculosis Infections) : Concomitantly, Nod2 interacts with and activates caspase-1 , resulting in increased levels of IL-1ß
Saïd-Sadier et al., Biomed J 2012 (Inflammation) : Recent research has revealed that DAMPs and PAMPs synergize to permit secretion of pro-inflammatory cytokines such as interleukin-1ß (IL-1ß) : PAMPs stimulate synthesis of pro-IL-1ß, but not its secretion ; while DAMPs can stimulate assembly of an inflammasome containing, usually, a Nod-like receptor ( NLR ) member, and activation of the protease caspase-1 , which cleaves pro-IL-1ß into IL-1ß, allowing its secretion