◀ Back to WNT1

TP53 — WNT1

Text-mined interactions from Literome

Niemann et al., Cancer Res 2007 (Adenocarcinoma, Sebaceous...) : We propose that LEF1 NH ( 2 ) -terminal mutations play a dual role in skin cancer, specifying tumor type by inhibiting Wnt signaling and acting as a tumor promoter by preventing induction of p53
Momota et al., Oncogene 2008 (Disease Models, Animal...) : As elevated c-Myc expression, activation of Wnt/beta-catenin signaling and dysfunction of p53 are seen in human PNETs, we investigated what role these abnormalities have in the formation of PNETs
Reed et al., BMC cancer 2008 (Cell Transformation, Neoplastic...) : Although p53 dependent regulation of Wnt signalling activity is known to occur, the importance of these regulatory mechanisms during the early stages of intestinal neoplasia has not been demonstrated ... However, the physiological Wnt pathway regulation by p53 appears to be overwhelmed by Apc loss and consequently the activity of these regulatory mechanisms is not sufficient to modulate the immediate phenotypes seen following Apc loss
Lee et al., Proc Natl Acad Sci U S A 2010 : The expression of five Wnt ligand genes is robustly induced by various genotoxic and nongenotoxic insults in a p53 dependent manner
Carreras Puigvert et al., Science signaling 2013 (Wnt Signaling Pathway) : Together, our findings reveal a balance between p53 mediated elimination of stem cells ( through loss of pluripotency and apoptosis ) and Wnt signaling that attenuates this response to tune the outcome of the DDR
Kim et al., Cell cycle (Georgetown, Tex.) 2013 : Recent evidence indicates that the microRNA-34 (miR-34) family, a transcriptional target of the p53, directly suppresses a set of canonical Wnt genes and Snail, resulting in p53 mediated suppression of Wnt signaling and the EMT process