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CBL — VAV1

Pathways - manually collected, often from reviews:

• NCI Pathway Database TCR signaling in naïve CD4+ T cells: CBL (CBL) → LAT/GRAP2/SLP76/VAV1/ITK/PLCgamma1/CBL complex (LAT-GRAP2-LCP2-VAV1-ITK-PLCG1) (modification, collaborate)
  Rellahan et al., Exp Cell Res 2003
  Evidence: physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: CBL (CBL) → LAT/GRAP2/SLP76/VAV1/ITK/PLCgamma1 complex (LAT-GRAP2-LCP2-VAV1-ITK-PLCG1) (modification, collaborate)
  Rellahan et al., Exp Cell Res 2003
  Evidence: physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: VAV1/CBL/Ubiquitin complex (VAV1-CBL) → VAV1 (VAV1) (modification, collaborate) Miura-Shimura et al., J Biol Chem 2003*
  Evidence: assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: VAV1/CBL/Ubiquitin complex (VAV1-CBL) → CBL (CBL) (modification, collaborate) Miura-Shimura et al., J Biol Chem 2003*
  Evidence: assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: VAV1 (VAV1) → CBL (CBL) (modification, collaborate) Miura-Shimura et al., J Biol Chem 2003*
  Evidence: assay
• Reactome Reaction: CBL → VAV1 (reaction) Miura-Shimura et al., J Biol Chem 2003*, Marengère et al., J Immunol 1997*
• Reactome Reaction: CBL → VAV1 (indirect_complex) Brooks et al., J Immunol 2000, Marshall et al., J Exp Med 2000, Fujimoto et al., Immunity 2000, Baba et al., Proc Natl Acad Sci U S A 2001, Rodriguez et al., J Biol Chem 2001, Chiu et al., EMBO J 2002, Xu et al., J Immunol 2002, Coggeshall et al., Proc Natl Acad Sci U S A 1992, Sekiya et al., J Biol Chem 2004, Brooks et al., J Immunol 2004, Roifman et al., Biochem Biophys Res Commun 1992, Kim et al., Mol Cell Biol 2004, Carter et al., Proc Natl Acad Sci U S A 1991, Weng et al., J Biol Chem 1994, Roifman et al., Biochem Biophys Res Commun 1993, Chalupny et al., EMBO J 1993, Uckun et al., J Biol Chem 1993, de Weers et al., J Biol Chem 1994, Saxton et al., J Immunol 1994, Smit et al., J Biol Chem 1996, Kuwahara et al., Int Immunol 1996, Harmer et al., Mol Cell Biol 1997, Fu et al., J Biol Chem 1997, Bae et al., J Biol Chem 1998, Fu et al., Immunity 1998
• Reactome Reaction: CBL → VAV1 (direct_complex) Miura-Shimura et al., J Biol Chem 2003*, Marengère et al., J Immunol 1997*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CBL — VAV1 (physical association, affinity chromatography technology) Simmons et al., Immunity 2005*
• IRef Biogrid Interaction: CBL — VAV1 (direct interaction, pull down) Marengère et al., J Immunol 1997*
• IRef Biogrid Interaction: CBL — VAV1 (direct interaction, far western blotting) Marengère et al., J Immunol 1997*
• IRef Biogrid Interaction: CBL — VAV1 (physical association, affinity chromatography technology) Bertagnolo et al., Cell Growth Differ 2001*
• IRef Biogrid Interaction: CBL — VAV1 (physical association, affinity chromatography technology) Miura-Shimura et al., J Biol Chem 2003*
• IRef Biogrid Interaction: CBL — VAV1 (physical association, affinity chromatography technology) Marengère et al., J Immunol 1997*
• IRef Biogrid Interaction: CBL — VAV1 (physical association, affinity chromatography technology) Shen et al., J Biol Chem 2009*
• IRef Biogrid Interaction: CBL — VAV1 (physical association, affinity chromatography technology) Lottin-Divoux et al., Cell Signal 2006*
• IRef Biogrid Interaction: CBL — VAV1 (physical association, affinity chromatography technology) Peterson et al., Immunity 2008*
• MIPS CORUM LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated: LAT-PLC-gamma-1-p85-GRB2-CBL-VAV-SLP-76 signaling complex, C305 activated complex (CBL-GRB2-LAT-LCP2-PIK3R1-PLCG1-VAV1) Zhang et al., Cell 1998
• IRef Corum Interaction: Complex of LCP2-GRB2-PIK3R1-CBL-LAT-PLCG1-VAV1 (association, coimmunoprecipitation) Zhang et al., Cell 1998
• IRef Hprd Interaction: CBL — VAV1 (in vitro) Lin et al., Int Immunol 2001*, Marengère et al., J Immunol 1997*
• IRef Hprd Interaction: CBL — VAV1 (in vivo) Lin et al., Int Immunol 2001*, Marengère et al., J Immunol 1997*
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Zhang et al., Cell 1998
• IRef Intact Interaction: CBL — VAV1 (association, pull down) Marengère et al., J Immunol 1997*
• IRef Ophid Interaction: CBL — VAV1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Miura-Shimura et al., J Biol Chem 2003 : Cbl mediated ubiquitinylation and negative regulation of Vav ... Interaction with Cbl also induced the loss of phosphorylated Vav
Marengère et al., J Immunol 1997 : The interaction between Vav and c-Cbl is directly mediated via the SH2 domain of Vav and is dependent on tyrosine phosphorylation of c-Cbl
Bustelo et al., Oncogene 1997 : By contrast, expression of truncated Cbl-b proteins and of missense mutants analogous to those found in inactive Sli-1 proteins have no detectable effect on Vav activity