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PLD6 — TNF

Text-mined interactions from Literome

Heyninck et al., Anticancer Res 1999 (Fibrosarcoma...) : The reduced TNF-sensitivity of A20 expressing L929 cells was correlated with a decrease of TNF induced phospholipase A2 (PLA2), phospholipase C (PLC) and phospholipase D ( PLD ) activation
Beyaert et al., J Immunol 1993 : Characterization of the inositol bisphosphate isomers by HPLC analysis revealed that the TNF + LiCl induced increase in IPn levels was due to activation of a phospholipase C and not of a phospholipase D
De Valck et al., Eur J Biochem 1993 : TNF induced phospholipase D activity was observed 1 h before the onset of cell killing and gradually increased thereafter ... Subclones selected for resistance to TNF cytotoxicity did not show phospholipase D activation in response to TNF ... In contrast, when these subclones were treated with TNF in the presence of actinomycin D, TNF cytotoxicity as well as TNF induced phospholipase D activity could be restored ... TNF cytotoxicity and TNF induced phospholipase D activity were equally modulated by various drugs known to interfere with different steps in the TNF signaling pathway ... Phospholipase D activation was found not to be the result of cell killing per se, as a number of other cytotoxic reagents were unable to activate phospholipase D. Prelabeling of cells with [ 14C ] lysophosphatidylcholine indicated phosphatidylcholine as one of the substrates for TNF activated phospholipase D
De Valck et al., J Cell Biochem 1998 (Necrosis) : Moreover, a comparative study using TNF and anti-Fas antibodies as cell death stimuli showed that PLD and cPLA2 are specifically activated by TNF
Kang et al., Exp Mol Med 1998 (Leukemia, Promyelocytic, Acute...) : Both TNF-alpha and anti-Fas/Apo1 monoclonal antibody increased PLD activity in a dose dependent manner up to 200 U/ml and 200 ng/ml, respectively