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GSN — PLD6

Text-mined interactions from Literome

Banno et al., J Biol Chem 1999 : Here we showed in in vitro experiments that gelsolin inhibited recombinant phospholipase D1 (PLD1) and PLD2 activities but not the oleate dependent PLD and that this inhibition was not reversed by increasing PIP ( 2 ) concentration ... To investigate the role of gelsolin in agonist mediated PLD activation, we used NIH 3T3 fibroblasts stably transfected with the cDNA for human cytosolic gelsolin ... Gelsolin overexpression suppressed bradykinin induced activation of phospholipase C (PLC) and PLD ... PLD activation by phorbol myristate acetate or Ca ( 2+ ) ionophore A23187 was not affected by gelsolin overexpression ... Our results suggest that gelsolin modulates bradykinin mediated PLD activation via suppression of PLC and PKC activities but did not affect S1P mediated PLD activation
Steed et al., Biochemistry 1996 : This finding was verified by the co-immunoprecipitation of gelsolin and PLD activity as well as by the reconstitution of gelsolin- dependent nucleotide sensitive PLD activity by the addition of purified gelsolin-free PLD