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ABL1 — MTOR
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Redig et al., Leukemia & lymphoma 2011
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
A large body of evidence has established that
BCR-ABL regulates engagement and activation of
mammalian target of rapamycin (mTOR) and mitogen activated protein kinase ( MAPK ) signaling cascades
Sheng et al., Blood 2011
(Cell Transformation, Neoplastic...) :
We find that
BCR-ABL , through PI3K/AKT/FOXO4 signaling, transcriptionally up-regulates ATF5 expression and that ATF5, in turn,
stimulates transcription of
mammalian target of rapamycin ( mTOR ; also called mechanistic target of rapamycin ), a well established master negative-regulator of autophagy
Joha et al., Oncogene 2012
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Our findings provide new mechanistic insights into the
role of
mTORC2 in
BCR-ABL ( + ) cells and indicate that regulation by GILZ may influence TKI sensitivity