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Xiong et al., Oncogene 2011
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Several ribosomal proteins regulate p53 function by modulating MDM2 Daftuar et al., PloS one 2013
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Relevantly, a number of RPs have been shown to bind to MDM2 and inhibit MDM2 E3 ligase activity, leading to p53 stabilization and cell cycle arrest, thus revealing a RP-Mdm2-p53 signaling pathway that is critical for ribosome biogenesis surveillance