Wadgaonkar et al., J Biol Chem 1999
:
MDM2 blocked CBP/p300 recruitment in vitro and inhibited the interaction of the transactivating region of p53 with both the N- or C-terminal regions of CBP/p300 in a mammalian two-hybrid assay
Wei et al., J Biol Chem 2003
(Osteosarcoma) :
Wild-type MDM2 inhibited the ability of PML to stimulate the transcriptional activity of a GAL4-CBP fusion protein
Sánchez-Molina et al., Biochem J 2006
:
Furthermore, we provide evidence that Mdm2 ( murine double minute 2 ), in the presence of active H-Ras or N-Ras, induces CBP/p300 degradation in NIH 3T3 cells