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HIPK2 — MDM2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MDM2 — HIPK2 (physical association, affinity chromatography technology) Di Stefano et al., FEBS Lett 2005*
• IRef Biogrid Interaction: MDM2 — HIPK2 (physical association, affinity chromatography technology) Rinaldo et al., Mol Cell 2007*
• IRef Biogrid Interaction: MDM2 — HIPK2 (direct interaction, enzymatic study) Rinaldo et al., Mol Cell 2007*
• IRef Biogrid Interaction: MDM2 — HIPK2 (physical association, affinity chromatography technology)
• IRef Hprd Interaction: HIPK2 — MDM2 (in vivo) Di Stefano et al., FEBS Lett 2005*
• IRef Hprd Interaction: HIPK2 — MDM2 (in vitro) Di Stefano et al., FEBS Lett 2005*
• IRef Intact Interaction: MDM2 — HIPK2 (physical association, anti bait coimmunoprecipitation) Di Stefano et al., FEBS Lett 2005*
• IRef Intact Interaction: MDM2 — HIPK2 (physical association, pull down) Di Stefano et al., FEBS Lett 2005*
• IRef Intact Interaction: MDM2 — HIPK2 (physical association, anti tag coimmunoprecipitation) Di Stefano et al., FEBS Lett 2005*
• IRef Intact Interaction: MDM2 — HIPK2 (phosphorylation reaction, experimental interaction detection) Di Stefano et al., FEBS Lett 2005*
• MIPS Negatome - no physical interaction between proteins Interaction: HIPK2 — MDM2 (Absence of interaction, western blot) Wang et al., BMC molecular biology 2001*

Text-mined interactions from Literome

Di Stefano et al., FEBS Lett 2005 : We propose that HIPK2 contributes to drug induced modulation of MDM2 activity at transcriptional ( through p53Ser46 phosphorylation ) and posttranscriptional ( through p53 independent subcellular re-localization and proteasomal degradation ) levels
Rinaldo et al., Mol Cell 2007 : MDM2 regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage induced apoptosis
Rinaldo et al., Cancer Res 2009 : HIPK2 regulation by MDM2 determines tumor cell response to the p53 reactivating drugs nutlin-3 and RITA ... Gain- and loss-of-function experiments revealed the functional significance of MDM2 mediated HIPK2 regulation in cell decision between mitotic arrest and apoptosis in both types of p53 reactivation