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CASP7 — MDM2

Pathways - manually collected, often from reviews:

• BioCarta hiv-1 nef: negative effector of fas and tnf: Caspase 3/6 inactivated cell cycle/DNA repair proteins (CDC2L1/PARP1/RB1/PRKDC/MDM2/CDC2L2/NUMA1) → Caspase 7 (active) (CASP7) (degradation, collaborate)
  

Text-mined interactions from Literome

Bonini et al., J Neurosci Res 2004 : The z-VAD-fmk-sensitive apoptotic response requires a caspase dependent MDM-2 degradation, leading to p53 mitochondrial targeting accompanied by cytochrome c release and nucleosomal fragmentation
Wang et al., Oncogene 2004 : The caspase inhibitor, Z-VAD-FMK, blocked the decrease in Mdm2 as well as the increase in p53 resulting from Survivin disruption, indicating that Survivin regulates Mdm2 at the post-translational level
Pikkarainen et al., J Biol Chem 2009 : Finally, antisense oligonucleotide mediated reduction of H ( 2 ) O ( 2 ) -induced Mdm2 expression increased caspase 3 activation
Xie et al., Cancer cell international 2013 : The application of genistein, MDM2 inhibitor and XIAP inhibitor to the recovering HeLa cells caused persistent caspase activity and enhanced cell death ... The application of genistein, MDM2 inhibitor and XIAP inhibitor to the recovering HeLa cells caused persistent caspase activity and enhanced cell death