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APOB — TP53
Text-mined interactions from Literome
Napoli et al., FASEB J 2000
(Arteriosclerosis) :
Mildly oxidized
LDL also activated MAP and Jun kinases and
increased p53 and other transcription factors ( ATF-2, ELK-1, CREB, AP-1 )
Mazière et al., Biochem Biophys Res Commun 2000
:
Oxidized
LDL induces an oxidative stress and
activates the
tumor suppressor p53 in MRC5 human fibroblasts
Heinloth et al., Atherosclerosis 2002
:
Nitric oxide prevents oxidised
LDL induced
p53 accumulation, cytochrome c translocation, and apoptosis in macrophages via guanylate cyclase stimulation
Choi et al., J Nutr 2008
:
Moreover, oxidized
LDL increased luciferase activity of
p53 in endothelial cells transfected with a p53 promoter construct, the increase of which was strikingly downregulated by EGCG and hesperetin