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APOB — NOS3

Text-mined interactions from Literome

Mehta et al., Biochem Biophys Res Commun 2001 : Pretreatment of HCAECs with simvastatin or atorvastatin ( 1 and 10 microM ) reduced ox-LDL induced upregulation of LOX-1 and downregulation of eNOS ( both P < 0.05 ) ... These observations indicate that statins attenuate the effect of ox-LDL on eNOS expression
Mukherjee et al., Cell Mol Biol Incl Cyto Enzymol 2001 : Ox-LDL stimulated PKC activity of BAEC but it inhibited both eNOS activity and cAMP production
Pritchard et al., Free Radic Biol Med 2002 : n-LDL increased phospho-eNOS by 149 %, eNOS by approximately 34 %, and Cav-1 by 28 %, and decreased the association of hsp90 with eNOS by 49 %
Rodríguez et al., Atherosclerosis 2002 (Disease Models, Animal...) : Native LDL from HC, but not from HCV, induced a significant decrease in eNOS expression ... A similar effect could be demonstrated in vitro, by incubation of EC with native LDL, suggesting that the effect of physiologically modified LDL on eNOS could have a role in recovering vascular function
Ou et al., Circulation 2003 : Western analysis of eNOS immunoprecipitates was used to determine effects of LDL and L-4F on heat shock protein 90 (hsp90) interactions with eNOS
Zhu et al., Biochim Biophys Acta 2003 : We investigate the effect of LDL on eNOS regulation in human endothelial cells ( ECs ) ... In cultured ECs, a high level of LDL increased the abundance of eNOS and caveolin-1 (Cav-1) in the membrane caveolae and the association of eNOS with Cav-1
Fleming et al., Cardiovasc Res 2005 : ox-LDL , but not native LDL, induced a time- and concentration dependent decrease in the phosphorylation of eNOS on Thr ( 495 )
Bao et al., J Cardiovasc Pharmacol 2006 : Moreover, ox-LDL inhibited eNOS expression and increased LOX-1 expression, whereas FSBT pretreatment partly abolished these effects
Bao et al., Eur J Pharmacol 2006 : Isorhamnetin pretreatment inhibited the ox-LDL induced downregulation of eNOS , upregulation of lectin-like ox-LDL receptor-1, phosphorylation of the p38MAPK and translocation of NF-kappaB
Schalkwijk et al., Clin Hemorheol Microcirc 2007 : Mevastatin increased eNOS-expression , both in the presence and absence of Ox-LDL
Dong et al., J Cell Mol Med 2009 : Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthase
Liao et al., J Biol Chem 1995 : These results indicate that oxidized LDL regulates endothelial NOS expression through a combination of early transcriptional inhibition and post-transcriptional mRNA destabilization
Hamilton et al., J Clin Invest 1995 : The cooperative effects of IFN gamma and LPS on the expression of the inducible nitric oxide synthase gene were suppressed by oxidized LDL while the antagonistic effect of IFN gamma on LPS induced expression of the TNF receptor type II mRNA was not altered
Hernández-Perera et al., J Clin Invest 1998 : eNOS mRNA expression was reduced by oxidized LDL in a dose dependent fashion ( up to 57 % inhibition ), whereas native LDL had no effect