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APOB — CASP6

Text-mined interactions from Literome

Guo et al., Arterioscler Thromb Vasc Biol 2001 : CuSO ( 4 ) -oxidized LDL increased DNA fragmentation and caspase activities in the primary cultures of mouse aortic SMCs
Chen et al., Circ Res 2004 : Ox-LDL also activated caspase-9 and caspase-3, but not caspase-8 ... In other experiments, pretreatment of HCAECs with the caspase-9 inhibitor z-LEHD-fmk, but not the caspase-8 inhibitor z-IETD-fmk, blocked ox-LDL induced activation of caspase-3 and apoptosis ... As expected, pretreatment with the caspase-3 inhibitor DEVD-CHO inhibited ox-LDL induced activation of caspase-3 and resultant apoptosis
Neekhra et al., Invest Ophthalmol Vis Sci 2007 : LDL partially blocked 7kCh induced caspase-8 activity but increased caspase-12 activities, suggesting that caspase-8 and caspase-12 pathways are independent of each other
Wu et al., Invest Ophthalmol Vis Sci 2008 (Diabetes Mellitus, Type 2...) : In cell culture, HOG-LDL induced the activation of caspase , mitochondrial dysfunction, and apoptosis in HRCPs
Wu et al., Mol Cell Biochem 2012 : In addition, ox-LDL enhanced the activity of caspase9 and then caspase3
Fu et al., Vascul Pharmacol 2013 : Our results showed that in the presence of ox-LDL , XJP-1 significantly attenuated ox-LDL mediated cytotoxicity, apoptosis, caspase-3 activation, reactive oxygen species ( ROS ) generation, and NADPH oxidase subunit ( p22phox and p47phox ) expression in HUVECs
Lin et al., PloS one 2013 (Plaque, Atherosclerotic) : In in-vitro experiments showed that ox-LDL induced caspase-1 activation and this activation was required for ox-LDL induced macrophages lysis, IL-1ß and IL-18 production as well as DNA fragmentation