Litinskiy et al., Nat Immunol 2002
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In the presence of interleukin 10 (IL-10) or transforming growth factor-beta , BLyS and APRIL induce CSR from C ( mu ) to C ( gamma ) and/or C ( alpha ) genes in B cells, whereas CSR to C ( epsilon ) requires IL-4
Kim et al., J Leukoc Biol 2008
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In the present study, we examined the pathways by which TGF-beta1 and IFN-gamma induce BAFF expression to see if TGF-beta1 and IFN-gamma regulate B cell differentiation via macrophages ... IFN-gamma further augmented TGF-beta1 induced BAFF expression