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Bogush et al., J Biol Chem 2007
(Huntington Disease) :
We demonstrated that both the PI3K/Akt/mammalian target of rapamycin and the cdk5/p35 signal transduction pathways contribute to the induction of DARPP-32 protein levels by BDNF and that the effects are on both the transcriptional and translational levels
Santini et al., J Biol Chem 2012
(MAP Kinase Signaling System...) :
These studies demonstrate that, in D1R expressing MSNs, l-DOPA induced activation of ERK and mTORC1 requires DARPP-32 and indicates the importance of the cAMP/DARPP-32 signaling cascade in dyskinesia