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IL6 — TPO

Text-mined interactions from Literome

Kaser et al., Blood 2001 (Inflammation...) : To address whether IL-6 might act through TPO to increase platelet counts, TPO was neutralized in vivo in C57BL/10 mice treated with IL-6, and hepatic TPO mRNA expression and TPO plasma levels were studied ... IL-6 enhances TPO mRNA transcription in HepG2 cells
Ozkurt et al., Platelets 2010 (Multiple Myeloma) : TPO levels were higher in stage III than stage I ( p = 0.05 ) and stage II ( p = 0.03 ) patients in newly diagnosed MM. High TPO levels induced by IL-6 may sustain normal PLT counts despite bone marrow infiltration by plasma cells and decreased PLT half-life
Tominaga et al., Acta Endocrinol (Copenh) 1991 : Interleukin 6 inhibits human thyroid peroxidase gene expression ... Interleukin 6 ( 10 ( 4 ) -10 ( 5 ) U/l ) inhibited TSH induced thyroid peroxidase mRNA in a dose dependent manner, although the basal level of thyroid peroxidase mRNA expression was not suppressed by interleukin 6 ... Pretreatment with specific antibody against interleukin 6 selectively restored the inhibitory effect of interleukin 6 on thyroid peroxidase gene expression
Ashizawa et al., Acta Endocrinol (Copenh) 1989 : Both interleukin 1 alpha and beta inhibited TSH induced thyroid peroxidase mRNA in a dose responsive manner ; 10 ( 3 ) U/1 interleukin 1 caused maximal suppression of TSH induced thyroid peroxidase mRNA level to nearly basal levels ... These results demonstrate that interleukin 1 directly inhibits TSH induced thyroid peroxidase gene expression and provide further evidence for a paracrine role of interleukin 1 as a local inhibitor of thyroid hormone synthesis