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MTOR — RELA
Text-mined interactions from Literome
Minhajuddin et al., J Immunol 2005
:
Inhibition of mTOR by this approach promoted whereas over-expression of
mTOR inhibited thrombin induced transcriptional activity of
NF-kappaB , an essential regulator of ICAM-1 transcription ... Consistent with these data, we
observed a more efficient and stable nuclear localization of
RelA/p65 and, subsequently, the DNA binding activity of NF-kappaB by thrombin following
mTOR inhibition
Djavaheri-Mergny et al., J Biol Chem 2006
:
This repression is associated with an
NF-kappaB dependent activation of the autophagy inhibitor
mTOR
Brown et al., Ann Clin Lab Sci 2006
(Neoplasms, Squamous Cell...) :
Because the mammalian target of the rapamycin (mTOR) pathway contributes to the
activation of
NF-kappaB through
immunophilin/mTOR signaling , we investigated : ( a ) the immunohistochemical expression and state of activation and potential clinical significance of components of the mTOR signal transduction pathway in SCCT patients ( morphoproteomics ) ; and ( b ) the inhibitory effects of rapamycin on the growth and state of activation of mTOR in 2 HNSCC cell lines ( pharmacoproteomics )
Ghosh et al., Cancer Cell 2006
(MAP Kinase Signaling System) :
Furthermore, in TSC2 ( -/- ) MEFs, the rapamycin mediated inhibition of deregulated
mTOR activity
restored NF-kappaB activation and survival
Dan et al., Genes Dev 2008
(Prostatic Neoplasms) :
Akt dependent regulation of
NF-{kappa}B is
controlled by
mTOR and Raptor in association with IKK ... We show here that
mTOR downstream from Akt
controls NF-kappaB activity in PTEN-null/inactive prostate cancer cells via interaction with and stimulation of IKK
Park et al., Cancer Res 2009
(Brain Neoplasms...) :
However, unlike other signals that regulate mTOR activity without affecting its level, RIP1 negatively regulates
mTOR transcription via a
NF-kappaB dependent mechanism
Ahmed et al., Molecular cancer 2010
(Breast Neoplasms) :
Moreover, overexpression of
mTOR inhibits OPN induced
NF-kappaB and AP-1-DNA binding and transcriptional activity