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EIF4G1 — MTOR

Text-mined interactions from Literome

Kimball et al., Am J Physiol Endocrinol Metab 2000 : The results reveal that treating 18-h fasted pigs with rapamycin, a specific inhibitor of mTOR , before feeding prevented the activation of S6K1 and the changes in eIF4F complex formation observed in skeletal muscle and liver after feeding
Petroulakis et al., Br J Cancer 2006 (Cell Transformation, Neoplastic...) : mTOR affects the activity of the eIF4F complex by phosphorylating repressors of the eIF4F complex, the eIF4E binding proteins
Harris et al., EMBO J 2006 : mTOR dependent stimulation of the association of eIF4G and eIF3 by insulin ... Here, we present evidence that mTOR interacts directly with eIF3 and that mTOR controls the association of eIF3 and eIF4G ... This novel effect was blocked by rapamycin and other inhibitors of mTOR , and it required neither eIF4E binding to eIF4G nor eIF3 binding to the 40S ribosomal subunit
Prabhu et al., Oncogene 2007 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Experiments with rapamycin and the Bcr-Abl inhibitor, imatinib mesylate, in Bcr-Abl expressing cell lines and primary CML cells indicated that Bcr-Abl and mTORC1 induced formation of the translation initiation complex, eIF4F
Petroulakis et al., Br J Cancer 2007 : mTOR affects the activity of the eIF4F complex by phosphorylating repressors of the eIF4F complex, the eIF4E binding proteins
Vary et al., Alcohol Clin Exp Res 2008 : Furthermore, the data suggest that protein synthesis in rats fed a diet containing ethanol is limited by mTOR dependent reduction in phosphorylation of S6K1 ( Thr ( 389 ) ) and eIF4G ( Ser ( 1108 ) ) secondary to reduced phosphorylation of mTOR ( Ser ( 2448 ) )
Melemedjian et al., Molecular pain 2011 (Disease Models, Animal...) : Peripheral nerve injury induced reorganization of translation machinery in the peripheral nervous system of rats and mice, including enhanced mTOR and ERK activity, increased phosphorylation of mTOR and ERK downstream targets, augmented eIF4F complex formation and enhanced nascent protein synthesis
Grosso et al., PloS one 2011 : In spite of this, mTORc1 inhibition reduces eIF4F complex formation, and depresses translocation of TOP mRNAs on polysomes