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CHUK — MTOR
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Minhajuddin et al., J Immunol 2005
:
Analysis of the NF-kappaB signaling pathway revealed that inhibition of
mTOR potentiated
IkappaB kinase activation resulting in a rapid and persistent phosphorylation of IkappaBalpha on Ser32 and Ser36, a requirement for IkappaBalpha degradation
Dan et al., Cancer Res 2007
(Prostatic Neoplasms) :
Regulation of
mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by
I kappa B kinase alpha ... The experiments show that
IKK alpha controls
mTOR kinase activity in Akt-active, PTEN-null prostate cancer cells, with less involvement by IKK beta ... Additionally,
IKKalpha is
required for efficient induction of
mTOR activity downstream of constitutively active Akt expression
Dan et al., J Immunol 2008
:
Previously, we showed that activation of
mTOR in PTEN-deficient cancer cells
involves IkappaB kinase (IKK) alpha, a catalytic subunit of the IKK complex that controls NF-kappaB activation ... In this study, we have explored the
involvement of both
IKKalpha and IKKbeta in insulin- and TNF induced
mTOR activation