UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to MTOR

MTOR — RHOA

Pathways - manually collected, often from reviews:

NCI Pathway Database mTOR signaling pathway: mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5) → RHOA/GTP complex (RHOA) (regulation of actin cytoskeleton organization, activates) Sarbassov et al., Curr Biol 2004, Jacinto et al., Nat Cell Biol 2004
Evidence: mutant phenotype

Text-mined interactions from Literome

Zeidan et al., Mol Cell Biochem 2011 : Our results demonstrate a critical role for PI3K/mTOR/p70 ( S6K ) in leptin induced RhoA activation resulting in cardiomyocyte hypertrophy associated with GATA4 stimulation
Goncharova et al., Mol Cell Biol 2011 : Our data demonstrate that mTORC2 dependent activation of RhoA is required for TSC2-null cell growth and survival and suggest that targeting both mTORC2 and mTORC1 by a combination of proapoptotic simvastatin and cytostatic rapamycin shows promise for combinational therapeutic intervention in diseases with TSC2 dysfunction