Dentin et al., Nature 2007
(Diabetes Mellitus) :
Activated SIK2 in turn stimulated the Ser 171 phosphorylation and cytoplasmic translocation of TORC2 Liu et al., Endocrinology 2012
:
Overexpression of either SIK1 or SIK2 in 4B cells reduced nuclear TORC2 levels ( Western blot ) and inhibited forskolin stimulated CRH transcription ( luciferase assay )