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MTOR — PML
Pathways - manually collected, often from reviews:
-
NCI Pathway Database mTOR signaling pathway:
PML (PML)
→
mTORC1/PRAS40/DEPTOR/PML complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-PML)
(modification, collaborate)
Bernardi et al., Nature 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
PML (PML)
→
mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR)
(modification, collaborate)
Bernardi et al., Nature 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
mTORC1/PRAS40/DEPTOR/PML complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR-PML)
→
mTORC1/PRAS40/DEPTOR complex (MTOR-MLST8-AKT1S1-DEPTOR-RPTOR)
(modification, collaborate)
Bernardi et al., Nature 2006
Evidence: mutant phenotype, assay, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wang et al., Autophagy 2011
:
In contrast, rapamycin, the
mTOR kinase inhibitor, enhanced autophagy and
promoted ATRA induced
PML-RARa degradation and myeloid cell differentiation
Iwanami et al., Proc Natl Acad Sci U S A 2013
(Glioblastoma) :
Direct
mTOR inhibitors and EGF receptor (EGFR) inhibitors that block downstream mTOR signaling
promote nuclear
PML expression in GBMs, and genetic overexpression and knockdown approaches demonstrate that PML prevents mTOR and EGFR inhibitor dependent cell death