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HIF1A — MTOR
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zhong et al., Cancer Res 2000
(Anoxia...) :
Here we demonstrate that in human prostate cancer cells, basal-, growth factor-, and mitogen induced expression of
hypoxia-inducible factor 1 (HIF-1) alpha , the regulated subunit of the transcription factor HIF-1, is
blocked by LY294002 and rapamycin, inhibitors of PI3K and
FRAP , respectively
Tan et al., Cancer Cell 2004
(Neovascularization, Pathologic) :
We show that integrin linked kinase (ILK) stimulates the expression of VEGF by stimulating
HIF-1alpha protein expression in a PKB/Akt- and
mTOR/FRAP dependent manner
Gao et al., Toxicol Appl Pharmacol 2004
(Ovarian Neoplasms) :
Our results also indicated that the
mTOR/FRAP inhibitor, rapamycin,
inhibited 4-OHE2 induced
HIF-1alpha and VEGF-A expression
Majumder et al., Nat Med 2004
(Prostatic Neoplasms) :
These data suggest that the expansion of AKT-driven prostate epithelial cells requires
mTOR dependent survival signaling and activation of
HIF-1 alpha , and that clinical resistance to mTOR inhibitors may emerge through BCL2 expression and/or upregulation of HIF-1 alpha activity
Hwang et al., Carcinogenesis 2004
(Prostatic Neoplasms) :
Phosphatidylinositol-3
kinase/Akt/mammalian target of rapamycin signaling was also
involved in vanadate induced
HIF-1alpha expression, but it was independent of AMPK signaling pathway
Phillips et al., J Biol Chem 2005
(Anoxia...) :
A molecular analysis of these events indicated that augmented CXCR4 expression was regulated by the phosphatidylinositol
3-kinase/PTEN/AKT/mammalian target of rapamycin signal transduction pathway,
activation of
hypoxia inducible factor (HIF) 1alpha , and ultimately HIF-1 dependent transcription of the CXCR4 gene
Michaylira et al., Cancer Biol Ther 2006
(Cell Transformation, Neoplastic...) :
HIF-1alpha activity was found to be required in Akt induced melanocyte transformation and tumor growth and it was
suppressed greatly by
mTOR inhibition with rapamycin
Lee et al., Clin Cancer Res 2006
(Neoplasm Invasiveness...) :
In OVCAR-3 and PC-3 cells, the phosphoinositide
3-kinase/Akt/mammalian target of rapamycin/p70S6K and p42/p44 mitogen activated protein kinase pathways were
required for LPA induced
HIF-1alpha and VEGF expressions, whereas only the phosphoinositide 3-kinase/mammalian target of rapamycin/p70S6K pathway was important in SK-Hep1 cells
Land et al., J Biol Chem 2007
(Neoplasms...) :
Hypoxia-inducible factor 1alpha is
regulated by the
mammalian target of rapamycin (mTOR) via an mTOR signaling motif ... Our work shows that activation of
mTOR by Ras homologue enriched in brain (Rheb) overexpression potently
enhances the activity of
HIF1alpha and vascular endothelial growth factor ( VEGF ) -A secretion during hypoxia, which is reversed with rapamycin
Hasaneen et al., Am J Physiol Lung Cell Mol Physiol 2007
:
Our results show : 1 ) a significant increase in human lung microvascular endothelial cell ( HMVEC-L ) proliferation, migration, and tube formation following incubation in conditioned media ( CM ) from HASM cells exposed to mechanical strain ; 2 ) mechanical strain of HASM cells induced VEGF expression and release ; 3 ) VEGF neutralizing antibodies inhibited the proliferation, migration, and tube formations of HMVEC-L induced by the strained airway smooth muscle CM ; 4 ) mechanical strain of HASM induced a significant increase in hypoxia-inducible factor-1alpha ( HIF-1alpha ) mRNA and protein, a transcription factor required for VEGF gene transcription ; and 5 ) mechanical strain of HASM
induced HIF-1alpha/VEGF through dual phosphatidylinositol 3-kinase
(PI3K)/Akt/mammalian target of rapamycin (mTOR) and ERK pathways
Gelse et al., Osteoarthritis Cartilage 2008
(Cartilage Diseases) :
The functional
role of phosphatidylinositol 3-kinase
(PI3K)/mammalian target of rapamycin (mTOR) and mitogen activated protein kinase ( MEK ) /extracellular signal regulated kinase ( ERK ) signaling on BMP-2/IGF-1 induced
HIF-1alpha expression was assessed in vitro by employing specific inhibitors
Yuan et al., J Cell Physiol 2008
(Calcium Signaling) :
Thus, both increased
mTOR dependent
HIF-1alpha synthesis and decreased hydroxylase dependent HIF-1alpha degradation contribute to IH-evoked HIF-1alpha accumulation
Toschi et al., J Biol Chem 2008
:
Expression of
HIF1 alpha is
dependent on the
mammalian target of rapamycin (mTOR) and is sensitive to rapamycin ... These data indicate that although
HIF1 alpha is
dependent on both mTORC1 and
mTORC2 , HIF2 alpha is dependent only on mTORC2 ... These data indicate that although
HIF1 alpha is
dependent on both
mTORC1 and mTORC2, HIF2 alpha is dependent only on mTORC2
Petrella et al., Cancer Biol Ther 2009
(Carcinoma, Renal Cell...) :
Activation of
PI3K/Akt/mTOR leads to increased
HIF-1alpha expression in certain cancer cells, supporting the rationale of using mTOR inhibitors as anti-cancer agents
Zheng et al., Cell Biol Int 2009
(Polycystic Kidney, Autosomal Recessive) :
Therefore, we investigated the relationship between the decreased FPC and the protein levels of
mTOR and the inhibitory
effects of rapamycin on the expression of mTOR,
Hypoxia-inducible factor-1 alpha ( HIF-1alpha ) and vascular endothelial growth factor ( VEGF ) in the human 293T cell line
Pistollato et al., PloS one 2009
(Brain Neoplasms...) :
HIF-1alpha is
controlled at the transcriptional and translational level by
mTOR and, alike BMP, also mTOR pathway modulates glial differentiation in central nervous system ( CNS ) stem cells ... Here, we investigate the
role of
mTOR signaling in the regulation of
HIF-1alpha stability in primary GBM derived cells maintained under hypoxia ( 2 % oxygen )
Ji et al., Mol Pharmacol 2010
:
Stimulation of endogenous EP1 receptors in human HepG2 hepatocellular carcinoma cells recapitulated the normoxic up-regulation of
HIF-1 alpha observed in HEK cells, was sensitive to pertussis toxin, and
involved the activation of
mTOR signaling and phosphorylation of rpS6