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FOXP3 — MTOR
Text-mined interactions from Literome
Perl et al., Curr Opin Rheumatol 2009
(Calcium Signaling...) :
Mammalian target of rapamycin controls the expression T-cell receptor associated signaling proteins CD4 and CD3zeta through increased expression of the endosome recycling regulator HRES-1/Rab4 gene, mediates enhanced Ca2+ fluxing and skews the expression of tyrosine kinases both in T and B-cells, and
blocks the expression of
Foxp3 and the expansion of regulatory T-cells
Yurchenko et al., PloS one 2012
(Inflammation...) :
Lastly,
mTOR inhibition with the immunosuppressive drug, rapamycin,
stabilizes Foxp3 expression in T ( REG ) cells and strongly inhibits IL-17 but not ROR?t expression in reprogrammed Foxp3 ( - ) T ( REG ) cells
Chen et al., J Invest Dermatol 2013
(Psoriasis) :
mTORC2-PKBa/Akt1 Serine 473 Phosphorylation Axis Is
Essential for Regulation of
FOXP3 Stability by Chemokine CCL3 in Psoriasis
Zeng et al., Nature 2013
(Inflammation) :
By contrast,
mTORC1 does not directly
affect the expression of
Foxp3 or anti- and pro-inflammatory cytokines in T ( reg ) cells, suggesting a non-conventional mechanism for T ( reg ) -cell functional regulation