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SOX2 — WNT4

Text-mined interactions from Literome

Mansukhani et al., J Cell Biol 2005 (Synostosis) : Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation ... Sox2 is expressed in calvarial osteoblasts in vivo and we show that constitutive expression of Sox2 inhibits osteoblast differentiation and causes down-regulation of the expression of numerous Wnt target genes
Kormish et al., Dev Dyn 2010 (Neoplasms) : In some contexts, Wnt signaling also regulates SOX expression resulting in feedback regulatory loops that fine-tune cellular responses to beta-catenin/TCF activity
Holmes et al., Bone 2011 (Craniofacial Abnormalities) : We have previously shown that in osteoblasts Sox2 expression can be induced by Fgfs, and can inhibit Wnt signaling and differentiation
Wang et al., J Biol Chem 2013 (Breast Neoplasms...) : Consistently, SOX9 overexpression in BCa cell lines and transgenic SOX9 expression in breast epithelium caused increased LRP6 and TCF4 expression and Wnt/ß-catenin activation