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PTH — WNT2

Text-mined interactions from Literome

Kobayashi et al., Clinical calcium 2009 (Osteoporosis) : Activation of the PTH receptor increases Wnt signaling by down regulating expression of Dkk1 and sclerostin, endogenous inhibitors for Wnt signaling, and by directly activating LRP6, a Wnt co-receptor
Inoue et al., J Cell Biochem 2009 : Role of Smad3, acting independently of transforming growth factor-beta, in the early induction of Wnt-beta-catenin signaling by parathyroid hormone in mouse osteoblastic cells ... Here, we examined which actions of Smad3 are TGF-beta independent in stimulating the osteoblast phenotype and PTH induced Wnt-beta-catenin signaling
Guo et al., Cell Metab 2010 : To determine whether this suppression is essential for PTH mediated Wnt signaling and bone formation, we examined mice that overexpress Dkk1 in osteoblasts ( Dkk1 mice ) ... Despite these effects of Dkk1 overexpression, PTH still activated Wnt signaling in Dkk1 mice and in osteoblastic cells cultured from these mice ... Our findings indicate that the full actions of PTH require intact Wnt signaling but that PTH can activate the Wnt pathway despite overexpression of Dkk1
Cheng et al., Circ Res 2010 (Arteriosclerosis...) : Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis
Jilka et al., J Bone Miner Res 2010 (Body Weight) : Consistent with this contention, PTH , but not sRANKL, decreased the level of the Wnt antagonist sclerostin and increased the expression of the Wnt target genes Nkd2, Wisp1, and Twist1
Tian et al., Mol Cell Biochem 2011 : Parathyroid hormone regulates osteoblast differentiation in a Wnt/ß-catenin dependent manner ... These results clearly indicate that PTH stimulates Wnt/ß-catenin pathway in MC3T3-E1 cells and osteoblast differentiation markers expression was up-regulated by activation of Wnt/ß-catenin signaling
Fei et al., J Cell Physiol 2012 (Osteoporosis...) : Maximal bone anabolic effect of PTH also requires Wnt signaling
Bonnet et al., Proc Natl Acad Sci U S A 2012 : Furthermore, in vivo stimulation of Wnt-ß-catenin signaling by PTH , as evaluated in TOPGAL reporter mice, was inhibited in the absence of periostin ( TOPGAL ; Postn ( -/- ) mice )