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LPA — SETD2
Text-mined interactions from Literome
Lee et al., Clin Cancer Res 2006
(Neoplasm Invasiveness...) :
In the present study, we investigated whether
LPA activates
hypoxia inducible factor-1 (HIF-1) , a key transcriptional complex in tumor progression and metastasis, thereby increasing the expression of VEGF
Lin et al., Am J Physiol Gastrointest Liver Physiol 2010
(Adenoma...) :
In vitro studies using HCT116 cells showed that
LPA induced cyclin D1, c-Myc, and
HIF-1a expression, which was attenuated by knockdown of LPA ( 2 )
Lee et al., J Biol Chem 2013
(Colonic Neoplasms) :
We have shown previously that
LPA stimulates
HIF-1a expression in colon cancer cells ... To determine the mechanism of
HIF-1a induction by
LPA , we compared the effect of LPA on HIF-1a in several colon cancer cell lines ...
LPA transcriptionally
induced HIF-1a in colon cancer cells ... Silencing of KLF5 inhibited
LPA induced
HIF-1a induction, suggesting that KLF5 is an upstream regulator of HIF-1a