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CCND1 — RAC2

Text-mined interactions from Literome

Gille et al., J Biol Chem 1999 : Activated PI 3-kinase induces cyclin D(1) transcription and E2F activity, at least in part mediated by the serine/threonine kinase Akt/PKB, and to a lesser extent the Rho family GTPase Rac
Lee et al., Mol Cell Biol 2000 (Cell Transformation, Neoplastic...) : Induction of cyclin D1 by NeuT involved Ras, Rac , Rho, extracellular signal regulated kinase, c-Jun N-terminal kinase, and p38, but not phosphatidylinositol 3-kinase
Kampfer et al., J Biol Chem 2001 : The present investigations revealed that cyclin D1 induction by transforming Ha-Ras is MEK- and Rac dependent and requires the PKC isotypes epsilon, lambda, and zeta, but not cPKC-alpha ... Therefore, we investigated a role for PKC isotypes in the Ras-Rac mediated transcriptional regulation of cyclin D1
Roovers et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : Inhibition of either MLCK or Rho kinase blocked sustained ERK signaling, but only Rho kinase inhibition allowed for the induction of cyclin D1 and activation of cdk4 via Rac/Cdc42
Roovers et al., Dev Cell 2003 : Surprisingly, inhibition of Rac dependent cyclin D1 expression by LIM kinase is independent of both cofilin phosphorylation and actin polymerization ... Instead, specific mutation of its nuclear localization and export sequences showed that LIM kinase acts in the nucleus to suppress Rac/Cdc42 dependent cyclin D1 expression
Klein et al., Cell cycle (Georgetown, Tex.) 2007 : In this report we characterize the mechanism of Rac mediated cyclin D1 gene expression in mouse embryonic fibroblasts ... Activated Rac strongly stimulated cyclin D1 gene transcription but did not alter the half-life of cyclin D1 mRNA ... Moreover, mouse cyclin D1 promoter-luciferase assays showed that Rac stimulated cyclin D1 gene expression without activating NFkappaB and that an essential Rac regulated promoter element is located far upstream or downstream of the cyclin D1 transcription start site
Yang et al., Biochem J 2008 (Breast Neoplasms) : Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK dependent induction of cyclin D1 and p21Cip1
Fournier et al., J Cell Sci 2008 : Rac dependent cyclin D1 gene expression regulated by cadherin- and integrin mediated adhesion ... Our previous studies described a pro-proliferative effect of E-cadherin in MCF10A cells, mediated by Rac, and we now show that Rac is required for cyclin D1 mRNA induction by both E-cadherin and integrin engagement
Klein et al., Curr Biol 2009 : In contrast, FAK dependent Rac activation, Rac dependent cyclin D1 gene induction, and cyclin D1-dependent Rb phosphorylation are strongly inhibited at physiological tissue stiffness and rescued when the matrix is stiffened in vitro