◀ Back to MTOR
MTOR — PTGS2
Text-mined interactions from Literome
Alpert et al., Biochem Pharmacol 2007
:
Because PKCdelta has also been shown to activate mTOR, we asked whether
COX-2 inhibitors
activate mTOR by a prior activation of PKCdelta
de Oliveira et al., Journal of neuroinflammation 2012
:
In contrast, the
mTOR inhibitor rapamycin
enhanced both
COX-2 and mPGES-1 immunoreactivity and the release of PGE2 and PGD2 ... Interestingly, NVP-BEZ235, a dual
PI3K/mTOR inhibitor,
enhanced COX-2 and reduced mPGES-1 immunoreactivity, albeit PGE2 and PGD2 levels were enhanced in LPS stimulated microglia ... Taken together, we demonstrate that blockade of mTOR and/or PI3K/Akt enhances prostanoid production and that PI3K/Akt, GSK-3 and
mTOR differently
regulate the expression of mPGES-1 and
COX-2 in activated primary microglia
Sidahmed et al., Phytomedicine 2013
:
In addition, PA exhibited a potent
FRAP value and significant
COX-2 inhibition