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IGF2 — VEGFA

Text-mined interactions from Literome

Bermont et al., Int J Cancer 2000 (Adenocarcinoma...) : In addition to its proliferative functions, IGF-I induces VEGF expression and participates in the maintenance of an angiogenic phenotype
Reinmuth et al., Clin Cancer Res 2002 (Colonic Neoplasms...) : RESULTS : IGF-I increased VEGF expression in parental and vector transfected cells, whereas IGF-I induction of VEGF mRNA and protein was abrogated in IGF-IR DN cells
Neid et al., J Biol Chem 2004 (Adenocarcinoma...) : Previously we have shown that in AsPC-1 pancreatic adenocarcinoma cells, insulin-like growth factor receptor ( IGF-IR ) regulates VPF/VEGF expression
Strammiello et al., Horm Metab Res 2003 (Bone Neoplasms...) : However, only the modulation of VEGF-A expression appears to be mediated by IGF-IR ... Analysis of the signaling mechanisms involved in constitutive or IGF induced expression and secretion of VEGF-A indicated that PI3-K and MAPK signaling pathways are both required for VEGF expression and production in ES cells
Kwon et al., J Invest Dermatol 2004 (MAP Kinase Signaling System...) : Insulin-like growth factor-II regulates the expression of vascular endothelial growth factor by the human keratinocyte cell line HaCaT ... Taken together, these results suggest that IGF-II enhances the expression of VEGF in HaCaT cells by increasing HIF-1alpha levels
Kim et al., Br J Dermatol 2005 : Northern blot analysis for the VEGF mRNA levels and an enzyme linked immunosorbent assay for the VEGF protein were performed to determine if IGF-II ( 100 ng mL(-1) ) can increase the VEGF expression levels with or without a pretreatment with protein inhibitors in primary normal human keratinocytes and HaCaT cells ... The IGF-II mediated VEGF induction was also effectively inhibited by a pretreatment with the tyrosine kinase inhibitor and Src inhibitor ... These results suggest that the tyrosine kinase-Src-ERK1/2 pathway and the PI3-kinase pathway are involved in IGF-II mediated VEGF expression, but PKC is negatively associated in the IGF-II mediated VEGF expression
Wang et al., Int J Oncol 2005 (Cell Transformation, Neoplastic...) : In this study, we have investigated the effects of PAX3-FKHR and IGF-II on the expression of muscle regulatory factors ( myf5, MyoD and myogenin ), and platelet derived growth factor-B ( PDGF-B ) and vascular endothelial growth factor ( VEGF ) in mouse C2C12 myoblasts in vitro
Slomiany et al., J Pharmacol Exp Ther 2006 (Anoxia) : However, IGF-1 stimulated a more significant increase in VEGF secretion ... In conclusion, IGF-1 regulates VEGF expression and secretion via HIF-1 dependent and -independent pathways
Wu et al., Cancer Immunol Immunother 2007 (Disease Models, Animal...) : Inhibition of IGF-IR by the A12 in vitro suppressed both constitutive and IGF-I induced secretion of VEGF , indicating that a putative anti-angiogenic mechanism associated with the A12 treatment may contribute to its anti-tumor effect
Stanek et al., J Clin Endocrinol Metab 2007 (Polycystic Ovary Syndrome) : However, insulin or IGF increased VEGF-A levels within 1 d and appeared to synergize with LH at 3 d. VEGF-A production by non-PCOS LGCs was more sensitive to IGF exposure, whereas PCOS cells were more sensitive to insulin
Ager et al., BMC developmental biology 2008 : IGF2 increased vascular endothelial growth factor expression in placental explant cultures, suggesting that IGF2 promotes vascularisation of the yolk sac
Ainscough et al., Exp Eye Res 2009 : In the course of studying the effects of IGFBPs on IGF mediated VEGF secretion and Vn-mediated phagocytosis in the RPE cell line ARPE-19, we have discovered that these cells avidly ingest synthetic microspheres ( 2.0 mum diameter ) coated with IGFBPs
Zisa et al., Am J Physiol Regul Integr Comp Physiol 2009 (Disease Models, Animal...) : VEGF also induced production of HGF, IGF2 , and VEGF by skeletal muscle ... VEGF also induced production of HGF, IGF2 , and VEGF by skeletal muscle
Zhang et al., BMC cancer 2010 (Colorectal Neoplasms...) : In addition, IGF-I could effectively induce the VEGF and VEGF-C mRNA expression and protein secretion in colorectal cancer cells expressing IGFIR molecules
Spiliotaki et al., Lung Cancer 2011 (Carcinoma, Non-Small-Cell Lung...) : Moreover, inhibition of IGF-IR signaling by AVE1642 reduced IGF-I induced VEGF production by NSCLC cells as well as the migratory capacity of HUVEC cells challenged with conditioned media from lung cancer cells previously exposed to IGF-I
Li et al., Cancer 2011 (Neovascularization, Pathologic...) : In addition, it has been demonstrated that IGF-IR signaling affects vascular endothelial growth factor ( VEGF ) expression in some other types of tumors ... IGF-IR/dn reduced VEGF expression, reduced the activation of both protein kinase B ( Akt ) and mitogen activated protein kinase ( MAPK ), and reduced vascular formation, indicating that IGF-IR/dn inhibited tumor growth in mice by inhibiting both angiogenesis and lymphangiogenesis
Piecewicz et al., PloS one 2012 : We confirmed that IGF-IGFR1 signaling stabilizes HIF1a and leads to up-regulation of VEGF during vasculogenesis in embryoid bodies
Goel et al., Cancer Discov 2012 (Prostatic Neoplasms) : VEGF/NRP2 signaling represses insulin-like growth factor-1 receptor ( IGF-IR ) expression and signaling, and the mechanism involves Bmi-1 mediated transcriptional repression of the IGF-IR
Wang et al., J Bone Miner Res 1996 (Bone Neoplasms...) : We have demonstrated that PTH, IGF-I , and most potently 1,25- ( OH ) 2D3 stimulate the mRNA expression and secretion of VEGF in human osteoblast-like cells, suggesting that one of the anabolic effects of 1,25- ( OH ) 2D3 on skeletal tissue may be mediated by VEGF produced by osteoblasts
Kim et al., Cancer Res 1998 (Carcinoma, Hepatocellular...) : The induction of VEGF by IGF-II was additively increased by hypoxia
Akagi et al., Cancer Res 1998 (Colonic Neoplasms) : We investigated the role of insulin-like growth factor (IGF)-I and IGF binding proteins ( IGFBPs ) in the regulation of vascular endothelial growth factor ( VEGF ) expression in colon cancer cells and the mechanism by which this regulation occurs ... In experiments using transient transfection of VEGF promoter-reporter constructs into HT29 cells, IGF-I increased the activity of the VEGF promoter, and pretreatment of HT29 cells with dactinomycin abrogated the induction of VEGF mRNA by IGF-I