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ATF4 — MTOR

Text-mined interactions from Literome

Adams et al., J Biol Chem 2007 : Insulin mediated induction of ATF4 required the mammalian target of rapamycin complex 1, was required for the activation of a genetic program for the cellular uptake of essential amino acids and the synthesis of nonessential amino acids and aminoacyl-tRNAs, and was coupled to the repression of Foxo dependent genes needed for protein and lipid catabolism
Jin et al., Free Radic Biol Med 2009 : Activating transcription factor 4 and CCAAT/enhancer binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress ... In this study, we show that activating transcription factor 4 (ATF4) and CCAAT/enhancer binding protein-beta ( C/EBP-beta ) negatively regulate mTOR via Redd1 expression in response to oxidative and ER stress
Babcock et al., J Biol Chem 2013 : Although bortezomib induces eukaryotic initiating factor 2a phosphorylation, mTORC1 activity was also required for downstream induction of the UPR transcription factors ATF4 and CHOP by a mechanism involving increased expression of c-MYC