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SFRP5 — WNT4

Pathways - manually collected, often from reviews:

• KEGG Wnt signaling pathway: SFRP1/SFRP2/SFRP4/SFRP5 → WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B (protein-protein, inhibition)
  

Text-mined interactions from Literome

Pilcher et al., Brain Res Gene Expr Patterns 2002 : Here we report the cloning and developmental expression pattern of the Xenopus orthologue of secreted Frizzled related protein 5 ( sFRP5 ), an endogenous inhibitor of Wnt signaling
La et al., Di Yi Jun Yi Da Xue Xue Bao 2004 (Liver Neoplasms) : [ Anti-oncogene p53 induced expression of secreted frizzled related protein , a Wnt signaling inhibitor ]
Marsit et al., Cancer Res 2005 (Disease Progression...) : Epigenetic silencing of the secreted frizzled receptor proteins ( SFRP ), antagonists of the WNT pathway, leads to constitutive WNT signaling, altering cell morphology and motility
Rodriguez et al., Nat Neurosci 2005 : Here we show that secreted Frizzled related protein 1 ( SFRP1 ), a proposed Wnt signaling inhibitor , can directly modify and reorient the growth of chick and Xenopus laevis retinal ganglion cell axons
Zi et al., Cancer Res 2005 (Neoplasm Invasiveness...) : The ability of Frzb/secreted Frizzled related protein 3 ( sFRP3 ) to inhibit Wnt signaling and the localization of Frzb/sFRP3 on chromosome 2q to a region frequently deleted in cancers have led some investigators to hypothesize that Frzb/sFRP3 is a tumor suppressor gene
Koza et al., PLoS Genet 2006 (Body Weight...) : In particular, elevated expression of SFRP5 , an inhibitor of Wnt signaling, the imprinted gene MEST and BMP3 may be causally linked to fat mass expansion, since differences in gene expression observed in biopsies of epididymal fat at 7 wk of age ( before the high-fat diet ) correlated with adiposity after 8 wk on a high-fat diet
Nojima et al., Oncogene 2007 (Carcinoma...) : Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer
Gumz et al., Clin Cancer Res 2007 (Carcinoma, Renal Cell...) : In an effort to gain a better understanding of signaling events in clear cell RCC ( cRCC ), we investigated the antitumor activity of secreted frizzled related protein 1 ( sFRP1 ), a negative regulator of Wnt signaling
Schlange et al., Breast Cancer Res 2007 (Breast Neoplasms) : Most breast tumors show hypermethylation of the promoter region of secreted Frizzled related protein 1 ( sFRP1 ), a negative WNT pathway regulator , leading to downregulation of its expression
Dufourcq et al., Am J Pathol 2008 (Neovascularization, Pathologic) : Our previous work has shown a role for secreted Frizzled related protein-1 ( sFRP-1 ), a proposed Wnt signaling inhibitor , in neovascularization after an ischemic event and demonstrated its role as a potent angiogenic factor
Satoh et al., Genesis 2008 : Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse
Kunke et al., Biochem Biophys Res Commun 2009 : In contrast, Wnt pathway inhibition in neurospheres, induced by retroviral overexpression of either Dkk1 or sFRP5 , robustly increased the gliogenesis at the expense of neurogenesis
Trenkmann et al., Ann Rheum Dis 2011 (Arthritis, Rheumatoid) : As a target gene of EZH2 the authors identified secreted frizzled related protein 1 ( SFRP1 ), an inhibitor of Wnt signalling, which is associated with the activation of RASF, and show that SFRP1 expression correlates with the occupation of its promoter with activating and silencing histone marks
Mori et al., J Clin Invest 2012 (Insulin Resistance...) : Thus, our findings support a model of adipogenesis in which SFRP5 inhibits WNT signaling to suppress oxidative metabolism and stimulate adipocyte growth during obesity
Mao et al., Invest Ophthalmol Vis Sci 2012 (Wnt Signaling Pathway) : We previously discovered elevated levels of secreted frizzled related protein 1 ( sFRP1 ), the Wnt signaling pathway inhibitor , in the glaucomatous trabecular meshwork ( GTM ), and found that key canonical Wnt signaling pathway genes are expressed in the trabecular meshwork ( TM )
Shen et al., PloS one 2012 : Such a loss was averted by treatment of secreted Frizzled related protein 1 ( sFRP1 ), an inhibitor of Wnt signaling
Yamada et al., Biomaterials 2013 (Wnt Signaling Pathway) : In addition, SFRP3 inhibited non-canonical WNT signalling by binding WNT5A, which is a representative non-canonical WNT protein
Stuckenholz et al., PloS one 2013 : We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities