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MAPK4 — WNT3
Text-mined interactions from Literome
Coe et al., Br J Cancer 2006
(Carcinoma, Non-Small-Cell Lung...) :
Small cell lung cancer exhibited increased expression of MRP5,
activation of
Wnt pathway inhibitors, and upregulation of p38
MAPK activating genes, while NSCLC showed downregulation of CDKN2A, and upregulation of MAPK9 and EGFR
Bikkavilli et al., J Cell Sci 2008
:
Activation of p38
MAPK is
critical for canonical
Wnt-beta-catenin signaling
Jeong et al., Cell cycle (Georgetown, Tex.) 2009
:
In addition, PPARdelta increased protein kinase C ( PKC ), cytosolic phospholipase A ( 2 ) ( cPLA(2) ) and p38
mitogen activated protein kinase ( p38 MAPK ) phosphorylation, and
Wnt/beta-catenin activation
An et al., Bone 2010
:
As a mechanism for Wnt mediated mitochondrial biogenesis, we found that
Wnt increased the expression of PGC-1alpha, a critical molecules in mitochondrial biogenesis, through Erk and p38
MAPK pathway independent of beta-catenin signaling
Horst et al., Cancer Res 2012
(Cell Transformation, Neoplastic...) :
Differential
WNT activity in colorectal cancer confers limited tumorigenic potential and is
regulated by
MAPK signaling