◀ Back to WNT3

LRP1 — WNT3

Text-mined interactions from Literome

Tamai et al., Nature 2000 : In Xenopus embryos, LRP6 activated Wnt-Fz signalling, and induced Wnt responsive genes, dorsal axis duplication and neural crest formation
Bafico et al., Nat Cell Biol 2001 : Wnt signalling through beta-catenin is mediated by the Fz receptor and a recently identified low-density-lipoprotein-receptor related co-receptor, LRP6/Arrow
Schweizer et al., BMC cell biology 2003 : Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors
Semënov et al., J Biol Chem 2005 (Bone Diseases, Developmental) : We show here that SOST antagonizes Wnt signaling in Xenopus embryos and mammalian cells by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt induced Frizzled-LRP complex formation
Stemmer et al., Oncogene 2008 (Colorectal Neoplasms) : Here, we demonstrate that snail increases Wnt reporter gene activity induced by beta-catenin, LRP6 or dishevelled, and also promotes transcription activated by GAL4-beta-catenin fusion proteins
Korol et al., Dev Biol 2008 : N1 does not bind LRP or Kremen nor inhibit Wnt signaling and has had no known function
Kawata et al., J Cell Physiol 2010 : Our findings also indicate that the onset of hypertrophy during endochondral ossification appears to be particularly dependent on the WNT and PKC signaling initiated by LRP1
Bhat et al., J Cell Biochem 2010 : DKK-1 protein blocks upregulation of the TCF-luciferase reporter by the Wnt3-Fz1 chimera, suggesting involvement of LRP in Wnt3-Fz1 signaling
Kawata et al., J Cell Sci 2012 : We have previously reported that LRP1 regulates WNT-ß-catenin and protein kinase C signaling in chondrocytes, represses the hypertrophy of chondrocytes during endochondral ossification and that LRP1 is colocalized with a ligand, CCN family member 2 ( CCN2 ; also known as connective tissue growth factor, CTGF ), which conducts endochondral ossification, in chondrocytes