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CDK14 — WNT3
Text-mined interactions from Literome
Chim et al., J Clin Pathol 2010
(Thrombocythemia, Essential) :
Methylation of genes regulating cell-cycle check-point ( INK4
cyclin dependent kinase inhibitors ), apoptosis ( XAF1 ), adhesion ( CDH13 ), JUNB and
Wnt signalling ( soluble Wnt inhibitors ) has been implicated in pathogenesis of haematological and epithelial cancers
Davidson et al., Trends Cell Biol 2010
:
This concept has now been substantially strengthened with the finding that the mitotic
CDK14/cyclin Y complex
promotes Wnt signaling through phosphorylation of the LRP6 co-receptor, a key regulatory nexus in the Wnt/beta-catenin pathway