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MTOR — PTEN
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Simpson et al., Mol Cell Biol 2001
(Breast Neoplasms) :
In addition,
PTEN , LY294002, and rapamycin, an
inhibitor of
mammalian target of rapamycin , caused a reduction in the molecular weight of IRS-2 and an increase in the association of IRS-2 with PI3K
Tee et al., Semin Cell Dev Biol 2005
(Disease...) :
Recent studies reveal that the tuberous sclerosis complex (TSC)-1/2,
PTEN , and LKB1 tumor suppressor proteins tightly
control mTOR
Chang et al., Invest New Drugs 2005
(Anemia...) :
Loss of
PTEN , which is common in glioblastoma multiforme ( GBM ),
results in activation of the
mammalian target of rapapmycin (mTOR) , thereby increasing mRNA translation of a number of key proteins required for cell-cycle progression
Levitt et al., Biochem Biophys Res Commun 2005
(Glioma) :
However, the rapamycin analog CCI-779 did not affect IGFBP-2 expression, suggesting that the
PTEN induced decrease in IGFBP-2 expression is not attributable to decreased
mTOR signalling
Cheung et al., Trends Mol Med 2006
(Leukemia) :
Thus, the regulation of HSCs and leukemic cells seems to be governed by cell-context
dependent ,
PTEN mediated regulation of
mTOR
Steelman et al., Oncogene 2008
(Breast Neoplasms) :
Interference with the lipid phosphatase activity of
PTEN was
sufficient to activate
Akt/mTOR/p70S6K signaling
Sherbakova et al., Mol Biol (Mosk) 2008
(Prostatic Neoplasms) :
Transfection of
PTEN into PTEN-deficient PC3 as well as rapamycin treatment
caused the inhibition of
PI3K/Akt/mTOR signaling and resulted in cell sensitization to the action of doxorubicin and vinblastine
Chan et al., Cell Biol Int 2009
:
Collectively, these findings suggest that PP2A and
PTEN may be
involved in fine tuning the regulation of
Akt/tuberin/mTOR/p70S6K in PC12 cells by M ( 4 ) mAChR and TrkA, respectively
Li et al., Mol Cancer Ther 2009
(Glioblastoma...) :
We also assessed the experimental therapeutic effects of combining anti-HGF/c-Met approaches with
PTEN restoration or
mTOR inhibition ... These preclinical studies show for the first time that PTEN loss amplifies c-Met induced glioblastoma malignancy and suggest that combining anti-HGF/c-Met approaches with
PTEN restoration or
mTOR inhibition is worth testing in a clinical setting
Bleau et al., Cell stem cell 2009
(Glioma) :
In this cell population, Akt, but not its downstream target
mTOR , regulates ABCG2 activity, and loss of
PTEN increases the SP
Han et al., Clin Cancer Res 2009
(Chordoma) :
Strikingly, expression of
PTEN , a negative
regulator of
mTORC1 signaling, was not detected or significantly reduced in chordoma derived cell lines and primary tumors
Wang et al., Zhongguo Fei Ai Za Zhi 2010
(Carcinoma, Non-Small-Cell Lung...) :
PTEN could negatively
regulate mTOR signal pathway and inhibit its activity
Liu et al., Nat Neurosci 2010
(Spinal Cord Injuries) :
Forced upregulation of mTOR activity in corticospinal neurons by conditional deletion of
Pten , a negative
regulator of
mTOR , enhanced compensatory sprouting of uninjured CST axons and enabled successful regeneration of a cohort of injured CST axons past a spinal cord lesion
Morrow et al., J Clin Oncol 2011
(Breast Neoplasms...) :
Phosphatase and tensin homolog (PTEN) is a dual phosphatase that counteracts the PI3K function ;
PTEN loss
leads to activation of the Akt cascade and the downstream
mammalian target of rapamycin (mTOR)
Li et al., Mol Cell Biochem 2012
(Endometrial Neoplasms) :
Loss of
PTEN promoted cell proliferation and
led to significant increases in the levels of EGFR, phospho-EGFR, AKT, phospho-AKT, and
phospho-mTOR proteins
Leibinger et al., Neurobiol Dis 2012
(Optic Nerve Injuries) :
Similar effects are achieved by the genetic deletion of
phosphatase and tensin homolog (PTEN) and subsequent
mammalian target of rapamycin (mTOR) activation
Jung et al., Oncogene 2013
(Carcinoma, Non-Small-Cell Lung...) :
Pharmacological inhibition of phosphatidyl inositol 3-kinase or transfection with wild-type PTEN suppressed phosphorylation of Akt,
mTOR and STAT3 ( Y705 ), sphere formation, and CXCR4 expression in A549/GR cells, whereas mutant
PTEN enhanced these events
Habib et al., Genes & cancer 2011
:
These novel data provide evidence that loss of TSC-2,
PTEN , and p53 as well as
activation of PI 3-K and
mTOR is associated with kidney cancer in the Eker rat, while sustained expression of TSC-2, PTEN, and p53 may prevent progression of kidney cancer in TSC patients
Wang et al., Cancer Res 2012
(Disease Models, Animal...) :
Here we describe a new genetically engineered mouse model of prostate cancer in which
PI3K-Akt-mTOR signaling is
activated by inducible disruption of
PTEN , and extracellular signal regulated kinase 1/2 ( ERK1/2 ) MAPK signaling is activated by inducible expression of a BRAF ( V600E ) oncogene
Weston et al., J Neurosci 2012
(Synaptic Transmission) :
We therefore performed an electrophysiological and morphological comparison of glutamatergic and GABAergic neurons in which
mTOR signaling was either
increased by loss of the repressor
Pten or decreased by treatment with rapamycin
Tanwar et al., PLoS Genet 2012
(Adenoma...) :
Loss of
PTEN , an upstream
regulator of
mTORC1 signaling, along with Lkb1 deletion significantly increased tumor burden in uteri and induced tumorigenesis in the cervix and vagina
Magee et al., Cell stem cell 2012
(Leukemia) :
Pten is therefore
required in adult, but not neonatal, HSCs to negatively regulate
mTORC2 signaling
Tumaneng et al., Nat Cell Biol 2012
:
We have identified the tumour suppressor
PTEN , an upstream negative
regulator of
mTOR , as a critical mediator of YAP in mTOR regulation
Mao et al., Neuroscience 2013
(Brain Ischemia...) :
Moreover,
PTEN expression persistently remained high in the ischemic brain over 14 days after MCAO, and BPV treatment
increased post-ischemic activation of Akt and
mTOR in the ischemic brain
Adhikari et al., PloS one 2013
(Primary Ovarian Insufficiency) :
Lack of
PTEN leads to increased phosphatidylinositol 3-kinase (PI3K)-Akt and
mammalian target of rapamycin complex 1 ( mTORC1 ) signaling in the oocytes