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ILK — MTOR

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of MTOR-ILK-RICTOR-RICTOR-ILK-MTOR (association, anti bait coimmunoprecipitation) McDonald et al., Cancer Res 2008*

Text-mined interactions from Literome

Yau et al., Cancer Res 2005 (Neovascularization, Pathologic...) : Inhibition of integrin linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR , Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine induced apoptosis in human orthotopic primary pancreatic cancer xenografts
Troussard et al., Cancer Res 2006 (Breast Neoplasms) : We show that inhibition of ILK activity with a pharmacologic ILK inhibitor, QLT-0267, results in the inhibition of PKB/Akt Ser473 phosphorylation, stimulation of apoptosis, and a decrease in mammalian target of rapamycin (mTOR) expression in human breast cancer cells
Verreault et al., Oligonucleotides 2009 (Neoplasms) : siRNA mediated integrin linked kinase suppression : nonspecific effects of siRNA/cationic liposome complexes trigger changes in the expression of phosphorylated-AKT and mTOR independently of ILK silencing