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JUN — SFTPC

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Jeon et al., J Lipid Res 2006 : In addition, SPC treatment induced the phosphorylation of c-Jun and extracellular signal regulated kinase, and SPC induced proliferation was completely prevented by pretreatment with the c-Jun N-terminal kinase (JNK)-specific inhibitor SP600125 but not with the MEK-specific inhibitor U0126
Berger et al., Proc Natl Acad Sci U S A 1995 (Niemann-Pick Diseases) : Here we show that SPC increased specific DNA binding activity of transcription activator AP-1 in electrophoretic mobility-shift assays ... Since the increase in AP-1 binding activity preceded the increase in c-fos mRNA, posttranslational modifications may be important in mediating the early SPC induced increases in AP-1 DNA binding activity ... Since the expression of many proteins with diverse functions is known to be regulated by AP-1, SPC induced activation of AP-1 may contribute to the pathophysiology of Niemann-Pick disease
Berger et al., Biochim Biophys Acta 1998 : We previously demonstrated that the sphingolipid, sphingosylphosphocholine (SPC) increased DNA binding activity of AP-1 proteins accompanying cellular proliferation