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CXCL2 — JUN
Text-mined interactions from Literome
Cinatl et al., Int J Mol Med 2005
(Colonic Neoplasms...) :
High hydrocortisone concentrations ( > or =50 microg/ml ) completely prevented increased DNA binding activity of
AP-1 and NF-kappaB and
inhibited up-regulation of
CXCL8 and CXCL10, but did not reduce chemokine expression to basal levels
D'Aversa et al., J Neurosci Res 2008
(AIDS Dementia Complex...) :
Gel shift analyses demonstrated that NFkappaB and
AP-1 , but not C/EBPbeta,
mediate microglial
CXCL8 production
Li et al., J Clin Endocrinol Metab 2011
(Inflammation...) :
In IL-1ß- or TNF-a stimulated first trimester decidual cells, NF?B inhibitor suppressed production of all six chemokines ;
JUN NH2-terminal kinase inhibitor
inhibited secretion of CCL2, CCL4, and CCL5 ; and MAPK kinase and p38 inhibitor decreased production of
CXCL8
Oh et al., J Immunol 2012
(Otitis Media) :
ERK2 dependent activation of
c-Jun is
required for nontypeable Haemophilus influenzae induced
CXCL2 upregulation in inner ear fibrocytes