Wong et al., J Biol Chem 2005
(Neuroblastoma...) :
Here, we demonstrate that Tat-coactivator interactions inhibit NGF- and brain derived neurotrophic factor-responsive CRE trans-activation and neurotrophin protection against apoptosis in PC12 and IMR-32 neuroblastoma cells
Nath et al., J Neurovirol 2012
:
Epicatechin and EGCG targets the brain derived neurotrophic factor (BDNF) and its precursor proBDNF signaling pathways, normalizing both Tat mediated increases in proapoptotic proBDNF and concomitant Tat mediated decreases in the mature BDNF protein in hippocampal neurons