UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to BDNF

BDNF — SOS1

Pathways - manually collected, often from reviews:

BioCarta role of erk5 in neuronal survival pathway: neurotrophin/TRkA complex (NTF3_BDNF_NGFB-NTRK1) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → GRB2/SOS1 complex (GRB2-SOS1) (modification, activates)
Qian et al., Neuron 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → SH2B family/GRB2/SOS1 complex (GRB2-SOS1) (modification, activates)
Qian et al., Neuron 1998
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: SHC/GRB2/SOS1 complex (SHC1-GRB2-SOS1) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
Holgado-Madruga et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: GRB2/SOS1 complex (GRB2-SOS1) → NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) (modification, collaborate)
Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: NGF/NGFR-active (NTRK1/NGF/NTF3/NTRK3/BDNF/NTRK2/NTF4/NTRK2) → FRS2 family/GRB2/SOS1 complex (GRB2-SOS1-FRS3_FRS2) (modification, activates)
Dixon et al., Biochim Biophys Acta 2006, Kouhara et al., Cell 1997
Evidence: mutant phenotype, physical interaction, other species